<p class='jove_content'>This manuscript describes how viral vector-mediated local gene delivery provides an attractive way to express transgenes in the central nervous system.  The protocol outlines all crucial steps to perform a viral vector injection in the substantia nigra of the rat to develop a viral vector-based animal model for Parkinson's disease. </p>

development-an-alpha-synuclein-based-rat-model-for-parkinson-s

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

In order to study the molecular pathways of Parkinson&#39;s disease (PD) and to develop novel therapeutic strategies, scientific investigators rely on ...

Institution - Leuven University Hospital - KU Leuven

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