<p class="jove_content">Here we present a detailed protocol of (A) the identification of a natural product with antibiotic activity, (B) the purification of the compound, (C) the first model of its biosynthesis, (D) genome sequencing/-mining and the (E) verification of the biosynthetic gene cluster.</p>

from-natural-product-to-its-biosynthetic-gene-cluster-demonstration

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from <em>Streptomyces diastatochromogenes</em> T&#252;6028

Streptomyces strains are known for their capability to produce a lot of different compounds with various bioactivities. Cultivation under different ...

Institution - Albert-Ludwigs-Universität Freiburg, Germany

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