<p class="jove_content">This protocol describes xenograft and orthotopic mouse models of human thyroid tumorigenesis as a platform to test microRNA-based inhibitor treatments. This approach is ideal to study the function of non-coding RNAs and their potential as new therapeutic targets.</p>

in-vivo-inhibition-of-microrna-to-decrease-tumor-growth-in-mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

MicroRNAs (miRNAs) are important regulators of gene expression through their ability to destabilize mRNA and inhibit translation of target mRNAs. An ...

Institution - Instituto de Investigaciones Biomédicas, CSIC-UAM

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