Grin Lens Assembly

A GRIN lens assembly is an optical imaging component built around a gradient-index lens, whose refractive index changes across its cross-section to guide light without relying solely on curved surfaces. In bioengineering systems, the lens is aligned and secured with complementary optical elements so that light from a sample is relayed through the assembly while preserving spatial information; the engineered index gradient continuously bends the light rays along the lens. These compact assemblies support miniature endoscopes, micro-imaging devices, and other tools for observing cells, tissues, and biomaterials in confined spaces. Their small size and imaging capability help enable minimally invasive measurements and high-resolution biological research.

Grin Lens Assembly - Related Videos

Research

JoVE EoE - Danio rerio (zebrafish)

Eye Lens Dissection: A Technique to Observe Zebrafish Lens Morphology

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2023

This video describes the protocol which is developed to dissect adult and larval zebrafish lenses to analyze cortical lens morphology and structural integrity of the lens sutures.

Research

JoVE Journal - Bioengineering

Automated Compression Testing of the Ocular Lens

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Cited by 2 •

2024

We present an automated method for characterizing the effective elastic modulus of an ocular lens using a compression test.

Simulating the Mechanics of Lens Accommodation via a Manual Lens Stretcher

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Cited by 9 •

2018

We present an efficient method of studying lens accommodation by using a manual lens stretcher. The protocol mimics physiological accommodation by pulling the zonules connected around the lens capsule, thereby, stretching the lens.

Research

JoVE Journal - Biology
Free Sample

Assembly, Loading, and Alignment of an Analytical Ultracentrifuge Sample Cell

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Cited by 21 •

2009

The analytical ultracentrifuge (AUC) sample cell holds sample and reference buffer and during experiments and is exposed to high vacuum and rotor speeds up to 60,000 rpm. This video will demonstrate the rigorous attention to detail necessary for assembly, loading and alignment of this very important component of an AUC experiment.

Using Baseplating and a Miniscope Preanchored with an Objective Lens for Calcium Transient Research in Mice

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Cited by 4 •

2021

The shrinkage of dental cement during curing displaces the baseplate. This protocol minimizes the problem by creating an initial foundation of the dental cement that leaves space to cement the baseplate. Weeks later, the baseplate can be cemented in position on this scaffold using little new cement, therebyreducing shrinkage.

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