Robotic Liquid Handler

A robotic liquid handler is an automated laboratory instrument that aspirates and dispenses liquids, enabling reproducible sample preparation and high-throughput workflows with less manual pipetting. Guided by programmed protocols, its pipetting head moves between tubes, microplates, or other labware, using disposable or fixed tips to transfer defined volumes while controlling liquid-handling sequence and mixing. In neuroscience, these systems support reagent distribution, cell-based assay preparation, nucleic acid workflows, and screening experiments, helping standardize measurements, reduce handling errors, and increase experimental throughput. Automation also improves scalability when studies require many samples or repeated experimental conditions.

Robotic Liquid Handler - Related Videos

Research

JoVE Journal - Developmental Biology
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Cited by 22 •

2015

The protocols described allow laboratories to perform scalable, adherent stem cell culture in high throughput with minimal labor, experience and equipment investment cost using a programmable liquid handling robot and 96-well plates. iPSCs passaged more than 20 times on this system maintained pluripotency, normal karyotypes and differentiated into cardiomyocytes.

High-throughput, Automated Extraction of DNA and RNA from Clinical Samples using TruTip Technology on Common Liquid Handling Robots

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Cited by 11 •

2013

TruTip is a simple nucleic acid extraction technology whereby a porous, monolithic binding matrix is inserted into a pipette tip. Consequently, the sample preparation format is compatible with most liquid handling instruments, and can be used for many medium to high-throughput clinical applications and sample types.

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

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Cited by 19 •

2017

Here, an automated workflow to perform modular DNA "device" assembly using a modular cloning DNA assembly method on liquid-handling robots is presented. The protocol uses an intuitive software tool for generating liquid handler picklists for combinatorial DNA device library generation, which we demonstrate using two liquid handling platforms.

Research

JoVE Journal - Biology
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Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

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Cited by 5 •

2008

The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. In this video, we utilize a 48-slot Mettler-Toledo MiniBlock equipped with filtration tubes and a Mettler-Toledo MiniMapper automated liquid handler was used to deliver the reagents and solvent. The parameters of interest were the concentration, the solvent...

Research

JoVE Journal - Bioengineering

Optimizing the Use of a Liquid Handling Robot to Conduct a High Throughput Forward Chemical Genetics Screen of Arabidopsis thaliana

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Cited by 10 •

2018

A high throughput screen of synthetic small molecules was conducted on the model plant species, Arabidopsis thaliana. This protocol, developed for a liquid handling robot, increases the speed of forward chemical genetics screens, accelerating the discovery of novel small molecules affecting plant physiology.

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