Mann-whitney U Test

The Mann-Whitney U test is a nonparametric statistical method for comparing two independent groups when data may not meet the assumptions required by a t-test. It combines observations from both groups, ranks them from smallest to largest, and evaluates whether one group tends to have higher or lower values than the other by calculating the U statistic and its associated significance. Researchers use the test for ordinal or continuous measurements, particularly with skewed data or small samples, to assess differences in distributions, central tendency, or group outcomes across biomedical, behavioral, and experimental studies.

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Research

JoVE Journal - Bioengineering
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Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model

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Cited by 12 •

2011

A method for seeding titanium blood-contacting biomaterials with autologous cells and testing biocompatibility is described. This method uses endothelial progenitor cells and titanium tubes, seeded within minutes of surgical implantation into porcine venae cavae. This technique is adaptable to many other implantable biomedical devices.

Research

JoVE Journal - Neuroscience

Activity of Posterior Lateral Line Afferent Neurons during Swimming in Zebrafish

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Cited by 6 •

2021

We describe a protocol to monitor changes in the afferent neuron activity during motor commands in a model vertebrate hair cell system.

In-vivo and Ex-vivo Calcium Imaging of an Olfactory Circuit Neuron in the Third-Instar Drosophila melanogaster Larva

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2025

We present calcium imaging protocols for a Drosophila larval olfactory neuron, using a topical tissue adhesive for immobilization. This method enhances stability, facilitating reliable in-vivo and ex-vivo experiments. Custom R scripts analyze calcium signals, providing an efficient platform for detailed neurophysiological research.

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury

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Cited by 15 •

2017

Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.

Isolation and Culture of Cells from the Nephrogenic Zone of the Embryonic Mouse Kidney

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Cited by 19 •

2011

In this report we describe a method for the isolation and culture of the progenitor cell niche from the embryonic mouse kidney that can be used to study signaling pathways regulating stem/progenitor cells of the developing kidney. These cultured cells are highly accessible to small molecule and recombinant protein treatment, and importantly also to viral transduction, which allows efficient manipulation of candidate pathways.

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