Extra-articular Fixation
Extra-articular Fixation - Related Videos
09:58
A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
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Cited by 9 •
2012
A 3D system of culturing human articular chondrocytes in high levels of synovial fluid is described. Synovial fluid reflects the most natural microenvironment for articular cartilage, and can be easily obtained and stored. This system thus can be used for studying cartilage regeneration and for screening therapeutics for treating arthritis.
08:30
Intra-articular Shoulder Injection for Reduction Following Shoulder Dislocation
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2023
Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA The anterior shoulder dislocation is one of the most common joint dislocations seen in emergency settings. In anterior shoulder dislocation, the humeral head is displaced out of the glenohumeral joint in front of the scapular glenoid, resulting in a loss of the articulation between the arm and the rest of the shoulder. This can be caused by a fall onto an abducted, extended, and externally...
12:37
3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
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Cited by 38 •
2015
Cartilage repair represents an unmet medical challenge and cell-based approaches to engineer human articular cartilage are a promising solution. Here, we describe three-dimensional (3D) biomimetic hydrogels as an ideal tool for the expansion and maturation of human articular chondrocytes.
09:18
Extra Cellular Matrix-Based and Extra Cellular Matrix-Free Generation of Murine Testicular Organoids
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Cited by 6 •
2020
Here, four methods for generating testicular organoids from primary neonatal murine testicular cells are described i.e., extracellular matrix (ECM) and ECM-free 2D and 3D culture environments. These techniques have multiple research applications and are especially useful for studying testicular development and physiology in vitro.
08:35
An Operant Intra-/Extra-dimensional Set-shift Task for Mice
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Cited by 13 •
2016
Attentional set-shifting cognitive abnormalities are a core feature of many psychiatric diseases. Here, we present the development of a novel automatic system for the effective study of attentional set-shifting abilities, executive functions and other cognitive abilities in mice with high translational validity to human studies.
FAQs
Extra-articular fixation transfers loads across the affected bone while maintaining alignment and joint congruity. Its mechanical purpose is to provide enough stability for a fracture or osteotomy without requiring hardware placement within the joint surface. In bioengineering studies, researchers therefore examine whether an implant configuration balances load transfer, structural support, and preservation of nearby articular cartilage.
Keeping fixation hardware outside the joint surface helps limit disruption of articular cartilage while supporting stabilization of the altered bone. This design priority connects mechanical performance with preservation of joint function. Evaluations can consequently consider not only whether the construct maintains alignment, but also whether it protects the joint environment during the intended repair or reconstruction.
Physiological loading provides a basis for examining how an implant construct responds to forces relevant to the body. Under these loading conditions, bioengineers can assess fixation performance, load transfer, and maintenance of alignment. The resulting information helps determine whether the design offers appropriate stability while supporting bone healing and limiting mechanical compromise of joint function.
Plates, screws, wires, and external fixation components serve as structural elements that transfer mechanical loads across a fractured or surgically altered region. Their inclusion in a construct allows researchers to study how fixation supports stability and alignment without placing components within the adjacent joint surface. The relevant outcome is the overall balance between mechanical support and tissue preservation.
A comprehensive evaluation can examine fixation performance, bone healing, implant mechanics, alignment, and protection of joint function. These outcomes address different aspects of success: mechanical behavior describes how the construct carries load, while healing and alignment indicate its effect on the treated bone. Joint-related assessment further considers whether stabilization preserves the surrounding articular environment.
This strategy is particularly relevant to fracture repair and osteotomy research. In both settings, investigators must consider how stabilization affects the altered bone while maintaining appropriate alignment and protecting nearby joint structures. It also provides a framework for comparing implant designs according to their mechanical behavior, contribution to healing, and ability to support continued joint function.
In bioengineering, the approach links implant design to measurable biological and mechanical outcomes. Researchers can evaluate whether a construct transfers physiological loads effectively, maintains stability and alignment, and supports bone healing without compromising joint function. This connection makes the strategy useful for studying implant mechanics alongside tissue preservation, rather than treating structural stability as the only endpoint.