Lower Limb Amputation

Lower limb amputation is the surgical removal of part or all of a lower extremity, a life-changing intervention used to remove nonviable tissue or manage severe injury and disease while preserving function where possible. It involves dividing bone and soft tissues, shaping and protecting the residual limb, and allowing healing before rehabilitation and prosthetic fitting. In bioengineering, knowledge of anatomy, biomechanics, tissue loading, and neural control guides the design of prosthetic limbs, sockets, sensors, and powered devices that support stable, energy-efficient movement. These technologies can improve mobility and independence, while research on implantable interfaces and personalized control aims to reduce discomfort, enhance sensory feedback, and enable more natural gait.

Lower Limb Amputation - Related Videos

Research

JoVE Journal - Medicine

Microscopic Replantation of Penile Glans Amputation Due to Circumcision

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Cited by 2 •

2022

The present protocol describes the emergency management of microscopic replantation of penile glans amputation due to circumcision.

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

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Cited by 3 •

2020

Lower limb amputation may occur even after angioplasty of obstructed vessels in Critical Limb Ischemia (CLI). Mononuclear Progenitor Cells (MPCs) reflect vascular repair. The present protocol describes the quantification of MPCs from circulation close to angioplasty, and its relationship with endothelial dysfunction and prediction of lower limb amputation.

Orthotopic Hind Limb Transplantation in the Mouse

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Cited by 24 •

2016

This novel model for orthotopic hind limb transplantation in the mouse, applying a non-suture cuff technique for super-microvascular anastomosis, provides a powerful tool for in vivo mechanistic immunological research related to vascularized composite allotransplantation (VCA).

Orthotopic Hind-Limb Transplantation in Rats

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Cited by 21 •

2010

Here we describe the orthotopic rat hind-limb transplantation procedure, which seems to be the gold standard in vivo model for composite tissue allotransplantation research.

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

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Cited by 1 •

2024

This experimental protocol outlines the use of a dual upper limb task-oriented robotic system for stroke patients with upper limb dysfunction. The findings indicate that this system can significantly improve stroke patients' upper limb function and daily living activities.

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