Non-destructive Sampling
Non-destructive Sampling - Related Videos
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Introduction to the Ultrasound Targeted Microbubble Destruction Technique
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Ultrasound Targeted Microbubble Destruction (UTMD) can be used to direct site-specific delivery of bioactive molecules, including therapeutic genes, to target organs accessible to ultrasound, such as the heart and liver1-6.
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Non-destructive Tests for Concrete Strength
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2024
The rebound hammer test, also known as the Schmidt hammer test, is a non-destructive technique for evaluating the hardness of concrete and, indirectly, the strength of concrete. It operates on the principle that the rebound of a spring-driven mass from a concrete surface correlates to the surface's hardness. The device comprises a mass within a tubular housing, a spring mechanism, and a plunger that strikes the concrete. Upon release, the energy imparted to the mass by the spring causes it to...
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Non-Destructive Evaluation of Regional Cell Density Within Tumor Aggregates Following Drug Treatment
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The present protocol develops an image-based technique for rapid, non-destructive, and label-free regional cell density and viability measurement within 3D tumor aggregates. Findings revealed a cell-density gradient, with higher cell densities in core regions than outer layers in developing aggregates and predominantly peripheral cell death in HER2+ aggregates treated with Trastuzumab.
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Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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Cited by 2 •
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A simple and non-destructive technique that measures the average content of drug substances in formulated drug products containing fluorine using low-field fluorine-19 (19F) time-domain (TD) nuclear magnetic resonance (NMR) is presented here. The technique can be applied to the development and manufacturing of drugs in the pharmaceutical industry.
11:34
Subsurface Defect Localization by Structured Heating Using Laser Projected Photothermal Thermography
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Cited by 7 •
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This method aims at locating vertical subsurface defects. Here, we couple a laser with a spatial light modulator and trigger its video input to heat a sample surface deterministically with two anti-phased modulated lines while acquiring highly resolved thermal images. The defect position is retrieved from evaluating thermal wave interference minima.
FAQs
By limiting physical disruption and processing-related changes, Non-destructive Sampling helps retain the specimen’s original chemical state and functional condition. This makes it possible to repeat measurements on the same material rather than comparing separate specimens. In biochemical studies, that repeated access supports time-based observations and can improve interpretation when biological properties change during an experiment.
Contamination can alter the composition being measured and make the resulting chemical information less representative of the original specimen. A minimally disruptive approach addresses this risk by reducing unnecessary handling and processing. The benefit is especially relevant when researchers analyze scarce or valuable biological material, because preserving sample integrity supports more reliable and reproducible comparisons.
Destructive processing may consume, alter, or physically disrupt the material before analysis, preventing equivalent follow-up measurements on the same specimen. Non-destructive Sampling instead emphasizes preserving essential structure, composition, or function during collection or analysis. This distinction matters when researchers need repeated measurements, direct condition comparisons, or continued access to a limited biological sample.
The workflow should prioritize a collection or measurement approach that limits disruption, contamination, and changes caused by processing. Researchers also need to consider whether the preserved material remains suitable for later examination and whether repeated measurements can be compared consistently. These decisions help align the sampling strategy with goals such as tracking change, conserving material, or assessing function.
It is particularly useful for enzyme studies, cellular research, biomarker analysis, and quality assessment. In each case, preserving the specimen can help maintain the chemical or functional features under investigation. The approach is also valuable when material is scarce or expensive, because the same specimen can support additional examinations instead of being exhausted by a single analytical step.
Non-destructive Sampling can provide chemical information while preserving the material for later analysis, enabling comparisons of the same specimen under different conditions. It also supports repeated observations that may reveal changes over time. In biochemistry, these capabilities can strengthen assessments of enzyme behavior, cellular properties, biomarkers, and sample quality by reducing variation introduced through separate specimens or extensive processing.