Pressure-driven Microfluidics

Pressure-driven microfluidics is a technique that controls small volumes of fluid by applying pressure across networks of microscale channels, enabling precise manipulation of liquids in bioengineering and other scientific fields. A pressure gradient forces fluid through the channels, while channel dimensions, fluid resistance, and flow conditions determine the resulting rate and direction; at these scales, flow is typically laminar and highly predictable. This approach supports controlled transport, mixing, cell handling, and reagent delivery in platforms for biological analysis, diagnostics, and tissue engineering. Its scalable, programmable flow control also helps integrate multiple experimental steps into compact lab-on-a-chip systems.

Pressure-driven Microfluidics - Related Videos

Research

JoVE Journal - Engineering

Pneumatically Driven Microfluidic Platform for Micro-Particle Concentration

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Cited by 3 •

2022

The present protocol describes a pneumatic microfluidic platform that can be used for efficient microparticle concentration.

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

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Cited by 4 •

2013

In this video we first describe fabrication and operation procedures of a surface acoustic wave (SAW) acoustic counterflow device. We then demonstrate an experimental setup that allows for both qualitative flow visualization and quantitative analysis of complex flows within the SAW pumping device.

A Microfluidic Device for Real-Time Imaging and Pressure Tracking During Biofilm Formation

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2026

Source: Kurz, D. L., et al. Microfluidic Platform to Study Bioclogging in Porous Media. J. Vis. Exp. (2022)The video demonstrates the use of a microfluidic device to study biofilm formation. A bacterial suspension is introduced into the microchannel, followed by incubation to allow biofilm development. Flow is then resumed, and pressure monitoring along with imaging is used to detect biofilm formation and pore blockage over time.

Research

JoVE Journal - Engineering

Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

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Cited by 2 •

2023

Flexible electrodes have a wide range of applications in soft robotics and wearable electronics. The present protocol demonstrates a new strategy to fabricate highly stretchable electrodes with high resolution via lithographically defined microfluidic channels, which paves the way for future high-performance soft pressure sensors.

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