Hydrogel Discs

Hydrogel discs are circular, water-swollen polymer networks that mimic aspects of soft biological tissues and provide a controllable platform for bioengineering research. Their three-dimensional structure forms when polymer chains crosslink, trapping water while allowing nutrients, signaling molecules, and waste products to diffuse through the material; changing polymer composition, crosslink density, or hydration tunes stiffness and transport. Researchers use hydrogel discs to investigate cell behavior, model tissue microenvironments, evaluate biomaterials, and develop systems for drug delivery or regenerative medicine. Their reproducible geometry also supports controlled comparisons of cell adhesion, growth, differentiation, and material performance.

Hydrogel Discs - Related Videos

Education

JoVE Science Education - Engineering

Collagen Hydrogels

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2023

Collagen is another widely used biomaterial that has found popularity in commercial applications, such as photography. Collagen has more recently been used in tissue engineering applications, by creating hydrogels that provide structure to engineered tissue. This video introduces collagen as a biomaterial, demonstrates how it is harvested from porcine skin, and shows how the material is used to create a hydrogel for tissue engineering applications. Finally, several applications of the material...

Hydrogel Synthesis

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2023

Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...

Research

JoVE Journal - Bioengineering

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

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Cited by 10 •

2017

This paper reports practical methods to prepare hydrogels in freestanding films and impregnated membranes and to characterize their physical properties, including water transport properties.

Research

JoVE Journal - Bioengineering

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

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Cited by 23 •

2022

This work describes straightforward, adaptable, and low-cost methods to fabricate microgels with extrusion fragmentation, process the microgels into injectable granular hydrogels, and apply the granular hydrogels as extrusion printing inks for biomedical applications.

Dissection and Mounting of Drosophila Pupal Eye Discs

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Cited by 6 •

2014

The goal of this technique is to enable researchers to perform dissection, immunostaining and mounting of pupal eye discs from Drosophila melanogaster of any age.

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