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Biomaterials Approaches to Salivary Gland Regeneration

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Guest Editor

Kimberly Jasmer

Kimberly Jasmer

University of Missouri, Department of Biochemistry

Dr. Jasmer earned her B.S. in Molecular, Cellular, and Developmental Biology from the University of Washington in 2009 and then her PhD from the University of Missouri in 2015 where she studied the role of heme oxygenase in melanoma tumorigenesis. Originally from Oregon, she is now an Assistant Research Professor of Biochemistry at the University of Missouri. Her current work focuses on the immunopathogenesis of inflammatory diseases of the salivary glands, namely autoimmune Sjögrens syndrome (SS) and chronic hyposalivation as a collateral side effect of head and neck radiotherapy. She is especially interested in understanding how Damage-Associated Molecular Patterns (DAMPs) coordinate epithelial-immune cell communication in these disease processes. The class of DAMPs she has focused on are released extracellular nucleotides, primarily extracellular adenosine triphosphate (eATP), and the purinergic P2 receptors that are activated in response to the release of extracellular nucleotides.  She is a previous recipient of a Sjögren’s Syndrome Foundation grant and is the current Program Chair for the American Association for Dental, Oral, and Craniofacial Research (AADOCR) Salivary Research Group. 

Collection Overview

Salivary gland damage as a result of radiotherapy for the treatment of head and neck cancers or due to autoimmune Sjögren’s syndrome remains a significant problem that causes xerostomia (sensation of dry mouth) and hyposalivation that can result in several oral complications (e.g., increased incidence of oral infections and dental caries, changes in saliva quality, and difficulties with swallowing and speech). A variety of approaches have been taken to regenerate salivary glands, including several biomaterials and tissue engineering approaches that are currently being investigated and optimized in pre-clinical animal models. Single- and double-layer cell sheets, hydrogels containing a variety of factors, and polymer scaffolds are a few of the many biomaterials approaches. This methods collection aims to highlight the biomaterials approaches for salivary gland regeneration and the models and techniques used for these studies.

 

Articles

Interrogating Cell-Cell Interactions in the Salivary Gland <em>via Ex Vivo</em> Live Cell Imaging
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Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging

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2023

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