
Ankit Tanwar
Albert Einstein College of Medicine, Department of Cell Biology, New York, USA
Dr. Ankit Tanwar is currently working as a Scientist in the Department of Cell Biology at Albert Einstein College of Medicine (AECOM), New York, USA. He is working on the NIH project entitled "Role of Glycosylation in Notch Signaling". Dr. Tanwar completed his master’s degree in Toxicology from Jamia Hamdard and bachelors in Biochemistry(H) from Shivaji College, University of Delhi; he then pursued his PhD degree in Toxicology from the Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Ministry of Defence, Govt. of India. Dr. Tanwar has received the Young Investigator Award for the development of a novel animal model in the field of Infectious Rheumatology from the International Conference on "Controversies in Rheumatology and Autoimmunity (CORA)” held in March 2017, Bologna, Italy. After the completion of his doctoral studies, he joined the Division of CBRN Defence, INMAS, DRDO as a project scientist. He has ~8 years of experience in the field of Toxicology and Drug discovery within the ambit of scientific guidelines (OECD, WHO, ICH). He is a key worker of a team who coined the word "Herbal Informatics" to derive drug molecules from natural products and actively working to provide the curative remedy for the disease of unknown etiology. Recently, his Model-Herbal Informatics has been used for the initial screening of emergency-approved drug by DCGI: 2-Deoxy-D-glucose (2-DG) for combating the COVID-19 situation in India. He has also published research papers to demystify the COVID-19 situation and provide effective strategic management. Dr. Tanwar has published >20 research articles in peer-reviewed journals and participated as an author of 2-books titled Demystifying "ESCAPE pathogen" and "EBOLA Virus". Dr. Tanwar has also received various awards and also serving as an Editorial Board and Co-chair of reputed Journals/organizations/conference awards committees and is also a member of reputed international scientific organizations such as ASH, SOT, USA etc. He actively participates in delivering talks in various conferences, seminars, and webinars. He also serves as a peer mentor at AECOM, New York, USA. His research expertise lies in the areas of Toxicology, Cell Biology, Hematopoiesis, Immunology, Rheumatology, Glycobiology, and Herbal Medicine.

Paula Videira
Faculdade de Ciências e Tecnologia Universidade NOVA de Lisboa
Dr. Paula Videira is motivated to understand the mechanisms that govern glycan expression and recognition and its impact in human biology and disease. She is an expert in Glycobiology and its interface with Immunology and Oncology. She is highly committed to translate research finding into innovative treatments, centered on patient needs. Her work currently focusses on three interconnected areas: i) mechanisms driving the expression of aberrant sialylated short O-glycans in cancers and its implications for tumour immunity and progression. ii) the role of sialylated glycans in the expression of immunomodulatory molecules and its role in curbing immune responses. iii) the impact of Congenital defects of glycosylation (CDG) in immune response and susceptibility to infection. She is an Assistant Professor at Faculdade de Ciências e Tecnologia/ Universidade NOVA de Lisboa (FCT-NOVA) and principal investigator of the Glycoimmunology Group at UCIBIO research unit. In the past few years her efforts were fruitful in several ways: (A) She published 99 research papers and four patents (as PI) describing various roles of glycans, in several top ranked journals (e.g. BBA, Molecular Oncology); a featured immunology article (doi: 10.4049/jimmunol.1890012); 11 invited reviews (one highly cited doi: 10.3390/ijms19051304), and clinical guidelines (doi: 10.1002/jimd.12024.) (B) Her students and herself (keynote speaker, invited speaker, moderator, chair) have presented unpublished data in several national and international conferences (e.g. SSIEM, AAI, PEGS). Her students' work was selected for several prestigious meetings for oral and poster presentations. (C) She was able to secure almost 4.5 million EUR for research plus 1.4 million EUR to spin-off our technology, including prestigious EU grants (Twinning, MSCA, EJPRD), prizes and research agreements with biopharmaceuticals. (D) She belonged to the Scientific council of COST and is currently part of the IAB of the Slovak Academy of Sciences and RD-Portugal, editorial board of Scientific Report, guest editor of Cancers and reviewer of several journals and international research applications. (E) She organizes international courses on Glycosciences as e-learning and Workshops and participated in the organization of several other meetings. (F) She co-founded the CDG&Allies-PPAIN, a unique patient-centric network, that gathers professionals and patient associations worldwide to foster research and awareness on rare diseases of glycosylation. (G) In 2019, she co-founded the spin-off CellmAbs, a biopharmaceutical developing immuno-oncology agents for tumour associated glycans. CellmAbs was elected to the top 30 by Biotecnika and featured by Labiotech and BIO-Europe 2020. Dr. Videira’s research is highly multidisciplinary and uses cutting edge methodologies as in vitro and in vivo assays, omics, bioinformatic tools, and patient-centric approaches with the ultimate goal of translating research findings into patient benefits.

Seema Chugh
University of Michigan, Department of Pathology, Ann Arbor, MI
Dr. Seema Chugh is currently working as a Senior Research Fellow in Dr. Arul Chinnaiyan’ s lab at Department of Pathology, University of Michigan. Dr. Chugh has completed her bachelors in Biochemistry from Panjab University (India). She further pursued a master's degree from All India Institute of Medical Sciences (AIIMS), where she studied the role of Th17 cells in bladder cancer. Dr. Chugh earned her PhD in Biochemistry and Molecular Biology from the University of Nebraska Medical Center in Omaha, NE. Her PhD thesis was entitled “Aberrant Glycosylation in Pancreatic Cancer Progression”. Dr. Chugh is very well versed in cancer glycobiology and has made significant contributions in the field by developing the first ever model of pancreatic cancer with aberrant O-glycosylation. She found that truncation of O-glycosylation in the context of an oncogenic background induces early onset of pancreatic ductal adenocarcinoma and metastasis. She published this study as a first author in Gastroenterology that was highlighted on the cover of their issue (Volume 155, Issue 5, November 2018). She received the Thomas Jefferson Ingenuity Award during her doctoral dissertation. To further advance her research interests in basic and translational cancer research, she joined Dr. Chinnaiyan’ s Lab as a postdoctoral fellow in January 2018. In Chinnaiyan lab, she has been leading multiple projects that are focused on Ras biology, cancer therapeutics, and prostate cancer glycobiology. She has presented her research work in multiple conferences and has received several honors and awards. Along with actively leading several research projects, Dr. Chugh has been passionate about teaching and has mentored several undergraduate and PhD students and has helped them in achieving their career goals. Dr. Chugh has 11 years of experience in cancer research that resulted in 6 first-author publications and 14 co-author publications in high impact journals. In addition to scientific writing, Dr. Chugh is actively engaged in scientific reading and has also assisted in reviewing manuscripts for severa; high tier journals. Her research expertise lies in the areas of Cancer Biology, Glycobiology, Ras Biology, and Cancer Therapeutics.
Glycobiology involves the study of the structure, function, and biology of carbohydrates, also called as glycans. This "sweet" science investigates a variety of biomolecules, including conjugates containing carbohydrate moieties. Glycans are diverse, complex molecules, and their functions are determined by their unique structures; however, the impact of glycosylation changes and sugar coats on glycosylated proteins on our cell surface, blood, many proteins, antibodies, extracellular matrix, and also on some viruses and bacteria, would be key to understanding health and various diseases. Different glycans such as O-glycans and N-glycans are highly decorated on the cell surface, thus influencing its development, growth, and other functions and are also involved in regulating the immune responses. Because of this prominent role, scientists consider glycans as the third chain of life after nucleotides (RNA/DNA) and peptides (proteins). Moreover, aberrant glycosylation can be an effective diagnostic and prognostic marker for many life-threatening diseases such as autoimmune diseases like Rheumatoid Arthritis (RA), Cancer, Infectious Diseases, etc. Accordingly, effective biochemical tools and high-throughput analytical techniques are required to appropriately reveal the glycan complexity, which can further be correlated to a specific function. Similarly, considering the fundamental role of glycans in cell communications and immune interactions, glycoproteins, and carbohydrates are becoming the targets of next-generation therapeutics, vaccines, and diagnostics. In this method collection, we have proposed to bring together immunology and glycobiology to define the landscape of glycan-based therapeutic techniques, tools, methods, and protocols that can be employed for several pathological conditions and therapeutic applications.
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Cited by 1
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2023
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Vanessa C. C. Luz1,2, Zélia Silva1,2, Patrícia Sobral1,2,3, Ankit Tanwar4,5, Rachel L. Paterson6, Paula A. Videira1,2,7
1Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2UCIBIO - Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 3LAQV and REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 4Department of Microbiology and Immunology, Albert Einstein College of Medicine, 5Department of Oncology, Albert Einstein College of Medicine, 6Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ciência e Tecnologia Avepark, Zona Industrial da Gandra, 7CDG & Allies - Professionals and Patient Associations International Network (CDG & Allies - PPAIN), Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa