Guest Editor
Collection Overview
Among the most serious health problems, infertility ranks third, after cancer and cardiovascular disease, in terms of its prevalence and impact on family quality of life. About half of all infertility cases are male, and infertile men are more likely to develop cancer, diabetes, and heart disease. Diagnostics and treatment of male infertility are challenging. A significant part of this problem is attributed to the complexity and unknown molecular mechanisms of male reproduction, such as spermatogenesis in the testis, sperm maturation in the epididymis, as well as sperm capacitation and acrosome reaction in the female reproductive tract. By identifying molecular targets and elucidating their roles in these cellular events, we will be able to better understand the pathogenic mechanisms that affect male reproduction and develop specific and sensitive treatments for male infertility. As the process of male reproduction is relatively isolated and specialized, the study of its molecular mechanism is likewise a relatively small field of research. This gives the field of research a sense of mystery and obscurity for people outside of it. This collection highlights the more specific technologies and bio-distinct approaches involved. For those looking for insight into the unique techniques in the field of male reproduction, this is a good resource; for researchers working on just a single aspect of male reproduction (such as spermatogenesis), this can also serve as both a good overview of the entire reproductive process, as well as an opportunity to build a connection between one's own research and other researchers.
