Skin is a dynamic, multifunctional organ that integrates barrier protection, immunity, sensation, thermoregulation, tissue repair, pigmentation, and host–microbiome interactions. Advances in molecular, cellular, genetic, imaging, and computational technologies are revealing increasingly complex mechanisms underlying skin homeostasis and disease. Nevertheless, major challenges remain, including incomplete understanding of barrier dysfunction, immune dysregulation, microbiome interactions, stem-cell and tissue-remodeling mechanisms, disease heterogeneity, chronic wound pathology, treatment resistance, and the limited ability of conventional models to faithfully reproduce human skin biology and clinical disease.

This Collection aims to provide a broad, multidisciplinary platform for research spanning fundamental skin biology, disease mechanisms, preclinical investigation, translational science, and clinical research. Contributions are welcomed across diverse aspects of cutaneous health and disease, including cellular and molecular processes, tissue and organ-level biology, host–environment interactions, immune and inflammatory mechanisms, skin aging and regeneration, disease pathogenesis and progression, as well as advances in diagnosis, biomarkers, therapeutics, drug delivery, and personalized medicine. The Collection will also encompass emerging technologies and innovative experimental, computational, and clinical approaches that enable deeper characterization of normal and diseased skin, improve disease modeling, and facilitate translation of basic discoveries into clinically relevant applications.

The Collection will feature methods articles, original research articles, review articles, and clinical case reports, enabling researchers to share innovative methodologies, mechanistic discoveries, clinical observations, and emerging therapeutic strategies.

By connecting fundamental skin biology with disease mechanisms and clinical translation, this Collection will facilitate interdisciplinary collaboration, improve experimental and disease models, identify therapeutic opportunities, and provide the scientific community with a comprehensive resource for advancing understanding, diagnosis, prevention, and treatment of skin disorders.