Recurrent miscarriage (RM) is an early pregnancy complication that affects approximately 1-3% of couples of childbearing age. The American Society for Reproductive Medicine (ASRM) understands RM as the loss of two or more spontaneous pregnancies before 20 weeks of gestation, not necessarily consecutive. RM has a great impact on the physical and mental health of patients, with approximately 5% of couples trying to conceive having two consecutive abortions. Currently, the etiology remains unknown in 50% of patients, and possible causative factors include chromosomal abnormalities, endocrine disorders, immune disorders, and anatomical abnormalities of the genital tract. Because the etiology of recurrent miscarriage is more complex, the treatment of RM are various while the results are unsatisfactory. At present, it mainly includes surgical treatment, preimplantation genetic diagnosis, hormone therapy, anticoagulation and immunomodulatory therapy. For unexplained recurrent miscarriage, its treatment still remains controversial. The aim of this collection is to explore innovative experiments and corresponding methods applicable to recurrent miscarriage and related fields. This collection includes, but is not limited to, exploring new treatment options for RM and prognostic evaluation; new clinical diagnostic markers and testing methods for RM; genetic diagnosis of RM; immunological testing for RM; etiology of RM; and care options for RM patients and their partners. In addition, this collection summarizes recent basic experimental techniques to elucidate RM pathogenesis.