Experimental and Analytical Research Methods in Skeletal Mechanobiology of Osteoporosis

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Guest Editor

Abhishek Kumar

Motilal Nehru National Institute of Technology Allahabad, Prayagraj, India

Dr. Abhishek Kumar Tiwari received a Bachelor of Technology (Hons.) degree in Mechanical Engineering from Uttar Pradesh Technical University, Uttar Pradesh, India, in 2011 and a Doctoral degree from the Department of Mechanical Engineering, IIT Ropar, in 2017 in the area of orthopedic biomechanics. He worked as an Assistant Professor with the Department of Mechanical Engineering, Manipal University, Jaipur, India, till 2018, and then moved to the Department of Applied Mechanics, Motilal Nehru National Institute of Technology (MNNIT) Allahabad, Prayagraj, India, as Assistant Professor. His current research focuses on the skeletal mechanobiology involved in bone disorders such as osteoporosis and osteogenesis imperfecta. In addition, his research group also investigates bone's adaptation to mechanical stimuli, canalicular fluid dynamics within the bone, and the design of orthopedic implants and instruments. His research interests include bone fracture healing, poromechanics, finite element simulations, and computational fluid dynamics.

Collection Overview

Osteoporosis is a serious bone disorder. Individuals with osteoporosis experience increased trabecular bone porosity and decreased cortical bone thickness, significantly lowering the bone's weight-bearing strength. This disease enhances the possibility of frequent bone fractures, which affect the quality of life, especially in the elderly. Clinical management of osteoporosis is a serious challenge for clinicians and orthopedic surgeons. Recent orthopedic research has established that exogenous mechanical stimulation in the form of prophylactic exercise can help prevent osteoporosis by improving bone strength.

The objective of this Methods Collection is to invite clinicians and orthopedic researchers to contribute innovative research methods developed to understand the mechanobiology of osteoporosis. This approach can also help in finding improved treatment strategies for osteoporosis mitigation. The scope of this collection includes:

Skeletal mechanobiology of osteoporosis.
Biomechanical interventions to prevent or cure osteoporosis.
In vivo and ex vivo innovative experiments on osteoporosis.
Combined treatment methods (pharmacological and biomechanical) to mitigate osteoporosis and other relevant research methods on osteoporosis.

Articles

Investigating the Effects of Infrared Therapy on Bone after High-intensity Treadmill Exercise Training

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2025

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Xiaohua Liu*¹, Lingli Zhang*², Xianji Wei², Bo Gao³

¹School of Exercise and Health, Shanghai University of Sport, ²College of Athletic Performance, Shanghai University of Sport, ³Institute of Orthopedic Surgery, Xijing Hospital, Air force Medical University

Abstracts

The effects of infrared thermography on bone after high-intensity treadmill exercise training

Xiaohua Liu¹

¹Shanghai University of Sport

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Effects of Mechanical force on Bone Homeostasis and Osteoporosis

Ziyi Jiang¹,

Zihan Huang²,

Yiwen Cui²,

Xiangru Huang^*2,

Siyuan Sun^*2

¹1Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine 2Washington University in St.Louis 3Shanghai Starriver Bilingual School,

²1Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine 4College of Stomatology, Shanghai Jiao Tong University 5National Center for Stomatology 6National Clinical Research Center for Oral Diseases 7Shanghai Key Laboratory of Stomatology