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TOPICAL COLLECTIONS

Tissue Engineering for Musculoskeletal System Repair and Regeneration
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Guest Editors

Wei Wei

Wei Wei

The Fourth Affiliated Hospital Zhejiang University School of Medicine

Dr. Wei Wei received his Bachelor of Engineering and Doctor of Engineering from Nanjing University of Science & Technology under the supervision of Prof. Wei Dong. He participated in research training under the supervision of Prof. Ali Khademhosseini at Harvard Medical School in 2016. Since 2018 he has been working with Prof. Hongwei Ouyang as a postdoctoral researcher at Zhejiang University-University of Edinburgh Joint Institute, Zhejiang University. In 2021, Wei joined the Fourth Affiliated Hospital Zhejiang University School of Medicine as Research Fellow. Dr. Wei has published more than 50 papers in SCI journals such as Cell Reports Physical Science, Advanced Functional Materials, Bioactive Materials, ACS Applied Materials & Interfaces, and Carbohydrate Polymers. Citations from Google Scholar are over 2000, and the h-index is 26 in 2023.

Xiaozhao Wang

Xiaozhao Wang

Zhejiang University-University of Edinburgh Joint Institute

Dr. Xiaozhao Wang received her Ph.D. at Zhejiang University under the supervision of Prof. Kui Cheng. She has been working with Prof. Hongwei Ouyang as a postdoctoral researcher at Zhejiang University-University of Edinburgh Joint Institute, Zhejiang University, since 2018. Dr. Wang has published nearly 30 papers in SCI journals such as Annals of Rheumatic Diseases, Nano Letters, Bioactive Materials, and ACS Applied Materials & Interfaces. Citations from Google Scholar are 502 in 2023.

Xianzhu Zhang

Xianzhu Zhang

The First Affiliated Hospital Zhejiang University School of Medicine

Dr. Xianzhu Zhang received his Bachelor’s degree in Pharmacy from Huazhong University of Science and Technology and his Doctor degree in Stem Cell and Regenerative Medicine under the supervision of Prof. Shufang Zhang at Zhejiang University. Since 2018 he has been working with Prof. Hongwei Ouyang as a postdoctoral fellow at Zhejiang University. In 2022, he joined the First Affiliated Hospital Zhejiang University School of Medicine as Research Fellow. Dr. Xianzhu Zhang has published more than 24 papers in SCI journals such as Nature Communications, Biomaterials, Advanced Healthcare Materials, Acta Biomaterialia, ACS Applied Materials & Interfaces, and Journal of Orthopaedic Translation. Citations from Google Scholar are over 1179, and the h-index is 12 in 2023.

Junxin Lin

Junxin Lin

Taizhou University Medical School

Dr. Junxin Lin pursued his Bachelor's degree in Animal Medicine from the College of Animal Sciences at Zhejiang University. He then went on to attain his Doctorate in Stem Cell and Regenerative Medicine from the School of Medicine at Zhejiang University, mentored by Prof. Hongwei Ouyang. Starting from 2020, Junxin has been conducting postdoctoral research under the guidance of Dr. Wanlu Liu at the Zhejiang University-University of Edinburgh Joint Institute. In 2023, he joined the Taizhou University Medical School as a lecturer. Dr. Lin has contributed to over 25 publications in SCI journals, including Bone Research, Signal Transduction and Targeted Therapy, Advanced Science, iScience, and the American Journal of Sports Medicine. According to Google Scholar, as of 2023, his works have been cited over 700 times, with an h-index of 11.

Collection Overview

Tissue engineering has enormous potential in repairing and regenerating damaged bone, cartilage, and muscle. This overview of the methods collection explores critical techniques used in musculoskeletal tissue engineering for dissection, repair, and regeneration, including:

 

  1. High-resolution dissection of functional tissues: Dissecting functional tissues provides a comprehensive understanding of musculoskeletal tissues and serves as a material model for their reconstruction.
  2. Cell sourcing and isolation: Commonly used cell types in musculoskeletal tissue engineering, such as mesenchymal stem cells (MSCs), chondrocytes, osteoblasts, and myoblasts, can be isolated from various tissue sources such as bone marrow, adipose tissue, and skeletal muscle.
  3. Scaffold fabrication and tissue-specific decellularized extracellular matrices: Techniques like electrospinning, 3D printing, and decellularization of natural tissues are employed to fabricate scaffolds. Emphasis is placed on acquiring various decellularized extracellular matrices (ECM) and characterizing their specific biomolecular, structural, and chemical properties in the musculoskeletal system.

Articles

A Multicolor 3D-STORM High-Resolution Visualization Protocol for Collagen Mineralization in Self-Assembled Recombinant Type I Collagen Fibrils

A Multicolor 3D-STORM High-Resolution Visualization Protocol for Collagen Mineralization in Self-Assembled Recombinant Type I Collagen Fibrils

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2026

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