Guest Editors
Elif Sarinay Cenik
University of Texas, Austin
Elif Sarinay Cenik is an Assistant Professor at the University of Texas, Austin. She uses genetic, genomic and computational approaches to study how the nucleolus and ribosome maturation are linked to epigenetics and multicellular growth coordination. She has a PhD in RNA biochemistry from Dr. Phillip Zamore’s lab, at Howard Hughes Medical Institute and University of Massachusetts Medical School. She has completed postdoctoral research in Dr. Maria Barna and then Dr. Andrew Fire’s lab at Stanford Medical School. She has been awarded by Stanford School of Medicine Dean's Postdoctoral Fellowship, The Walter V. and Idun Berry Postdoctoral Fellowship Program, UT Stars Program and CNS Catalyst Awards. Her lab is currently funded by NIH-NIGMS Maximizing Investigators' Research Award (R35) and Welch Foundation. She feels passionate about mentoring students, postdocs and producing high-quality, reproducible science.
Qiuxia Zhao
University of Texas, Austin
Dr. Qiuxia Zhao is a Postdoctoral Fellow at the University of Texas at Austin, where she works in the lab of Dr. Elif Sarinay Cenik. She received her PhD in genetics from Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, in 2019, with her research focused on studying miRNA biogenesis in Arabidopsis. Currently, Dr. Zhao’s research is centered on delineating how ribosome biogenesis in specific tissue contributes to coordination of organismal growth in C. elegans.
Collection Overview
Ribosomes are essential cellular structures responsible for protein synthesis in all living organisms, from bacteria to humans. Mutations or irregularities in ribosomal components can significantly impact cell function and are linked to various diseases. The study of ribosomes spans multiple scientific disciplines, including molecular biology, genetics, biotechnology, and medicine. To gain a comprehensive understanding of ribosomes in cellular processes and diseases, it is essential to explore their biogenesis, structure, function, and regulation.
This Methods Collection aims to bring together innovative techniques and tools for comprehensive ribosome research. It includes methods like mutagenesis, gene knockout, cryo-electron microscopy, mass spectrometry, sucrose gradient centrifugation, RNA footprinting, and structural and functional bioinformatics. These methods, ranging from genetic manipulation to high-resolution imaging, provide a versatile toolbox for investigating ribosomes at molecular, cellular, and structural levels. By integrating these innovative methodologies, this collection serves as a critical resource for researchers uncovering the mysteries of ribosomes and their multifaceted roles.
Articles
Abstracts
Using Mycobacterium smegmatis as a bioindicator for zinc-limited growth conditions
Allexa Burger1,
Sladjana Prisic*1
1University of Hawaii at Manoa
ALIBi: A method for Isolation of Subcellular Ribosome Subpopulations
Adele Xu1,
Craig Kerr1,
Kelsie Wysong1,
Maria Barna*1
1Department of Genetics, Stanford School of Medicine; Stanford, 94305, USA