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Tissue Organoids for Disease Modeling: Bridging the Gap between In Vitro and In Vivo Systems
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Zhi Dong Zhou

Zhi Dong Zhou

National Neuroscience Institute, Duke-NUS Medical School, Singapore

Dr. Zhi Dong Zhou graduated as a medical doctor in 1991 and completed five years of postgraduate clinical training in internal medicine. Subsequently, he acquired his Ph.D. and received postdoctoral training in Parkinson’s disease (PD) research at the National University of Singapore in 2003. Later, he joined the National Neuroscience Institute (NNI) as a member of the National PD Translational Bench to Bedside team and continues to work on PD.Currently, he is a Principal Investigator and a Clinician Scientist at NNI, as well as a regular-rank Assistant Professor in the Neuroscience and Behavioral Disorders (NBD) program at Duke-NUS Medical School. Additionally, he serves as a Principal Investigator for NMRC, SHF, and Duke-NUS grants.With interdisciplinary backgrounds in Medicine, Biochemistry, Biophysics, and Translational Neuroscience, Dr. Zhou possesses extensive scientific training, experience, and expertise in translational neuroscience research. His laboratory focuses on neurodegenerative disorders, with a particular emphasis on identifying and validating new therapeutic targets and biomarkers for PD and other neurodegenerative diseases. His research aims to uncover the molecular pathogenesis of human neurodegenerative diseases and to identify novel therapeutic targets and biomarkers to improve the diagnosis, prognosis, and treatment of these disorders.

Collection Overview

Organoids have emerged as powerful three-dimensional (3D) culture systems that recapitulate key structural and functional aspects of human tissues. These self-organizing structures, derived from pluripotent or adult stem cells, provide an advanced platform for studying disease mechanisms, drug responses, and regenerative medicine.

This special issue aims to highlight the latest advancements in tissue organoid technology for disease modeling, covering a broad range of applications, including neurodegenerative disorders, cancer, infectious diseases, and genetic syndromes. We welcome contributions on novel bioengineering strategies, patient-derived organoid models, high-throughput drug screening, and mechanistic insights into disease pathology.

Key Topics Include:

·       Innovations in organoid culture techniques and biomaterials

·       Organoid-based models for complex diseases

·       Integration of organoids with CRISPR gene editing, omics technologies, and microfluidic systems

·       Translational applications in personalized medicine

By bringing together experts in stem cell biology, bioengineering, and disease modeling, this issue will explore how organoid-based platforms are revolutionizing biomedical research and paving the way for more precise therapeutic strategies.

Articles

Measuring Intestinal Barrier Permeability by Detecting Flux of Fluorescent Tracers Across Human Colonoid Monolayers

Measuring Intestinal Barrier Permeability by Detecting Flux of Fluorescent Tracers Across Human Colonoid Monolayers

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2025

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