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TOPICAL COLLECTIONS

Methods for Studying Neurodegenerative Pathologies
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Guest Editors

David Medina

David Medina

Barrow Neurological Institute

Dr. David Medina is an assistant professor in the Translational Neuroscience Department at the Barrow Neurological Institute in Phoenix, Arizona. He earned his PhD from UT Health Science Center in San Antonio in 2013, where he studied the mechanisms underlying Alzheimer’s disease (AD) and frontotemporal dementia (FTD). In 2014, he began postdoctoral training focused on applying bioengineering techniques to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). Currently, Dr. Medina’s research investigates various neurodegenerative diseases, including ALS, FTD, and AD. He aims to identify shared molecular pathways using cellular and mouse models. His work employs multidisciplinary approaches, which include developing drug delivery techniques, conducting multi-omics analyses, discovering biomarkers, and creating in vitro models. Furthermore, his research evaluates innovative therapeutic strategies, such as small molecules, novel nanoparticle formulations, and viral vector approaches.

Ashley Boehringer

Ashley Boehringer

ASU-Banner Neurodegenerative Disease Research Center

Dr. Ashley Boehringer is a research assistant professor at the ASU-Banner Neurodegenerative Disease Research Center (NDRC) within the Biodesign Institute at Arizona State University (ASU). She earned her PhD in Neuroscience from ASU in 2018, where her research focused on a novel mutation associated with amyotrophic lateral sclerosis (ALS). Following her graduation, Dr. Boehringer began her first postdoctoral fellowship at the Weinberg ALS Center at Jefferson University, where she investigated the roles of neuronal activity and DNA damage in induced pluripotent stem cell (iPSC) models of ALS. In 2022, she continued her postdoctoral training at the NDRC at ASU, shifting her focus to Alzheimer’s and Parkinson’s diseases. Her current research encompasses all three neurodegenerative diseases and employs both iPSC and animal models, concentrating on synaptic changes associated with these conditions and the development of novel therapeutics.

Aaron Valentine

Aaron Valentine

Translational Neuroscience Department, Barrow Neurological Institute

Aaron Valentine is a research scientist in the Translational Neuroscience Department at the Barrow Neurological Institute in Phoenix, Arizona. He earned his Master of Science degree from Virginia Commonwealth University in 2023, where he researched new therapeutic options for treating brain metastasis of triple-negative breast cancer. Aaron will begin his PhD in Neuroscience at Arizona State University in Fall 2025. Currently, he collaborates with Dr. David Medina and Dr. Robert Bowser to study ALS and other neurodegenerative diseases.

Collection Overview

Neurodegenerative diseases affect millions of patients worldwide, yet there are very few effective treatments available. Understanding the biology underlying these conditions is essential for identifying new mechanisms, patient sub-populations, and potential therapeutics. This collection aims to present innovative methods for studying neurodegenerative diseases, focusing on biochemical approaches to measure various pathologies. For example, methods that utilize aptamers to visualize specific pathologies in different tissues. Additionally, we are interested in AI techniques that can enhance the quantification of pathologies in immunohistochemistry. These techniques could be applicable to a range of diseases.

Articles

Lentiviral-Induced Striatal Pathology as a Preclinical Model of Polyglutamine Spinocerebellar Ataxias
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Lentiviral-Induced Striatal Pathology as a Preclinical Model of Polyglutamine Spinocerebellar Ataxias

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2026

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Abstracts

Whole-Mount Optical Clearing of Rabbit Tenuissimus Muscle for Muscle Spindle Morphology Assessment

Emily Reedich1,

Katharina Quinlan1,

Marin Manuel*1

1University of Rhode Island