The vascular wall, comprising endothelial cells, smooth muscle cells, fibroblasts, and extracellular matrix, plays a central role in vascular health and disease. Its dysfunction or maladaptive remodeling is central to the development of numerous cardiovascular diseases, including atherosclerosis, aneurysm, restenosis, hypertension, and vasculitis.

This collection aims to showcase advanced scientific methodologies that deepen our understanding of the structure and biology of the vascular wall under physiological and pathological conditions. We invite submissions focused on experimental methods, research approaches, and technical innovations that advance the study of vascular wall disorders and diseases. Contributions related to clinical case-based methodologies are also highly encouraged.

Topics of interest include, but are not limited to:

• In vitro and in vivo models of vascular diseases (e.g., aneurysm, atherosclerosis, neointima formation)
• Spatial transcriptomics, single-cell analysis, and omics technologies applied to vascular tissues
• Advanced imaging and histological techniques for vascular wall analysis
• Gene editing and RNA-based technologies for vascular cell modulation
• Biomaterials and tissue-engineered models for vascular studies
• Methods for evaluating vascular inflammation and immune cell dynamics
• Cell-cell interaction studies within the vascular wall (e.g., endothelium-smooth muscle-fibroblast)
• Interventional and surgical approaches
• High-throughput platforms for drug discovery targeting vascular cells
• Case presentations highlighting rare or instructive vascular conditions

We welcome contributions that not only introduce or optimize experimental techniques but also demonstrate their relevance in advancing mechanistic insights or clinical translation in the context of vascular biology.