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TOPICAL COLLECTIONS

Light and Life: Non-destructive Molecular Spectroscopy Methods in Microbiology

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Melissa (Ying) Chen

Melissa (Ying) Chen

Optowares, Inc

Dr. Chen is a Senior Research Scientist at Optowares, Inc in Massachusetts, US. In her current position, she leads quantitative and qualitative spectroscopic analysis using machine learning in custom-designed, innovative products for US government clients. She received her PhD in physical chemistry from Boston University in 2017, under the supervision of Professor Lawrence Ziegler. Her research was on promoting surface enhanced Raman spectroscopy (SERS) for biosensing application. From Chlamydia trachomatis to cancer cells, she sought to identify unique metabolic biomarkers from these organisms in order to pinpoint their presence in complex mixtures, while also trying to understand the biochemical processes these molecules originated from. Her research was highly interdisciplinary, with a focus on potential clinical applications. Her enthusiasm for novel biosensing techniques stemmed from her undergraduate research experience on Whispering Gallery Mode (WGM) for ultrasensitive viral and protein detection at Polytechnic Institute of New York University, where she received her BS and MS degrees in chemistry in 2012.  

Collection Overview

Molecular spectroscopy methods, such as Fourier-transformed infrared and Raman spectroscopy, are versatile and non-destructive approaches for structural and functional analysis of micro-organism species. Each species, possessing unique composition of molecules, will interact with light energy in their own way. This fingerprinting capability of molecular spectroscopy gives researchers the ability to identify species and strains in complex mixture and to track biochemical changes in their own natural, intact states. Molecular spectroscopy, when coupled with deployable instruments and automated spectral analysis, will have great potential in microbiological research, as well as clinical and environmental applications. This collection invites publications in recent advances into the novel use of molecular spectroscopy in pathogen detection, the study of cellular response to exogeneous molecules and environmental stress, and the monitoring of communal behavior such as formation and growth of biofilm.

Articles

Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium
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Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium

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Cited by 5

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2022

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