The immune microenvironment plays a decisive role in shaping the onset, progression, and therapeutic response of cancer and inflammatory diseases. This complex and dynamic landscape involves intricate molecular and cellular interactions that govern immune surveillance, tolerance, tissue remodeling, and disease resolution or persistence. 

While significant progress has been made in immunotherapy and anti-inflammatory strategies, a deeper mechanistic understanding of immune regulation and dysregulation within tissue-specific microenvironments remains essential. Key challenges include dissecting the temporal and spatial heterogeneity of immune responses, overcoming therapeutic resistance, and translating laboratory findings into effective and durable clinical interventions.

This collection invites article contributions that explore the molecular mechanisms or therapeutic strategies targeting the immune microenvironment in cancer and inflammatory diseases. We welcome method-focused articles that present experimental techniques and original research articles that uncover mechanistic insights or therapeutic approaches.

This collection aims to provide a high-impact, interdisciplinary platform that integrates diverse techniques, mechanistic insights, and therapeutic advancements. It will serve as a valuable resource for researchers, clinicians, and drug developers working to reprogram the immune microenvironment for improved clinical outcomes in cancer and inflammatory disorders.