Advanced Methods for Developing Animal Models for Transplantation Research

TOPICAL COLLECTIONS

Guest Editors

Tao Liao

The First Affiliated Hospital of Shandong First Medical University

Dr. Tao Liao earned his master’s degree from Sun Yat-sen University in China in 2017 and his PhD from Southern Medical University in China in 2025. Currently, he serves as a principal investigator and attending physician in the Department of Urology at the First Affiliated Hospital of Shandong First Medical University. His research focuses on transplant immunity, encompassing the development of animal models for studying transplant rejection, the mechanisms of rejection, and novel prevention and treatment strategies.

Jianning Wang

The First Affiliated Hospital of Shandong First Medical University

Dr. Jianning Wang currently serves as the vice president, chief physician, and doctoral supervisor at the First Affiliated Hospital of Shandong First Medical University in Jinan, China. He earned his MD in Clinical Medicine from Shandong University and completed specialized training at Harvard Medical School. As a senior urological surgeon, Dr. Wang specializes in kidney transplantation and genitourinary oncology. His research focuses on two main areas: Advancing kidney transplantation by studying postoperative infection and rejection mechanisms, utilizing gut microbiome analysis and hyperspectral imaging, as well as innovating surgical techniquesEnhancing the efficacy of targeted therapies for renal cell carcinoma. In addition, Dr. Wang plays an active role in shaping national medical standards as a committee member of China’s National Kidney Transplantation Technology Medical Quality Control Center. He also serves as the chairman of the Organ Transplantation Branch of the Shandong Medical Association.

Collection Overview

Organ transplantation is the preferred method for addressing end-stage organ failure. However, the inflammatory response associated with rejection and ischemia-reperfusion injury remains a significant factor contributing to allograft dysfunction. Transplant rejection can be categorized into hyperacute rejection, acute rejection, and chronic rejection, depending on the timing and severity of the rejection. Additionally, rejection can be classified based on the primary immune cells involved, which include T cell-mediated rejection and antibody-mediated rejection.

The development of animal models is essential for exploring the pathogenesis, diagnosis, and new strategies for managing transplant-related diseases, particularly rejection and ischemia-reperfusion injury. Moreover, methods for creating various types of rejection models differ significantly. This Methods Collection seeks to compile methodologies for developing animal models related to transplant diseases, with a particular focus on rejection and ischemia-reperfusion injury. We especially encourage submissions that establish models for different types of rejection.