Immune-based therapies, including monoclonal antibodies, cell engagers, immune-targeting peptides, and engineered immune cells, are revolutionizing treatment approaches for cancer and autoimmune diseases. This Methods Collection will highlight advanced experimental platforms designed to evaluate therapeutic efficacy and safety, with a particular emphasis on translational and preclinical studies.

The focus will be on functional assays that clarify the roles of T cells and NK cells in targeted immunotherapies, as well as techniques for characterizing cytokine responses, immune cell activation, and tissue-specific targeting. The collection will feature protocols relevant to monoclonal and bispecific antibodies, peptide-based targeting systems, and novel immune modulators.

By providing high-quality, reproducible methods for assessing immune efficacy and immunotoxicity, this collection aims to accelerate the development of next-generation therapies and support translational research pipelines in both academic and industrial settings. Researchers will benefit from comprehensive resources that cover immune mechanism discovery, biomarker development, and preclinical safety evaluation.