Guest Editors
Mengnan Liu
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University
Dr. Mengnan Liu works in the Department of Cardiovascular Medicine at the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University. He completed his postdoctoral training at Zhejiang University. His primary research focuses on pharmacological and basic integrative medicine research for preventing and treating cardiovascular and cerebrovascular diseases.
Li Chen
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University
Dr. Li Chen is a researcher in the Department of Neurology at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University. Her primary focus is on cell biology and clinical medicine. Specifically, she investigates the molecular mechanisms of traditional Chinese medicine in relation to cardiovascular and cerebrovascular diseases. Her research also includes studying the dynamic changes in mitochondrial function under hypoxic conditions and examining ischemia-reperfusion injury in the heart and brain.
Mingtai Chen
Shenzhen Traditional Chinese Medicine Hospital
Dr. Mingtai Chen is a master's supervisor at Guangzhou University of Chinese Medicine and an attending physician at Shenzhen Traditional Chinese Medicine Hospital. His research focuses on preventing and treating cardiovascular and metabolic diseases using traditional Chinese medicine. Dr. Chen has led and participated in three projects funded by the National Natural Science Foundation of China.
Jinwen Wu
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University
Dr. Jinwen Wu is a researcher in the Department of Cardiovascular Medicine at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, China. Her primary research interests focus on the use of traditional Chinese medicine in managing cardiovascular diseases, as well as strategies for chronic disease management.
Collection Overview
Cardio-cerebrovascular diseases are among the leading causes of global mortality and disability. A thorough understanding of their pathological mechanisms and the development of effective therapies are essential. High-quality animal models are crucial as they provide a foundational basis for this research.
This collection aims to compile and present standardized, highly reproducible methods for establishing animal models of cardio-cerebrovascular diseases with strong clinical relevance. It covers common conditions such as myocardial infarction, heart failure, stroke (both ischemic and hemorrhagic), atherosclerosis, and hypertension.
Through detailed video demonstrations, the collection will offer researchers clear and intuitive operational guidelines. It will address key challenges in current model construction, including significant variations in techniques, a lack of transparency in operational details, and inconsistent validation standards.
This comprehensive approach will enhance research reliability and allow for better comparability of results. It will also accelerate the translation of basic research findings into clinical applications, ultimately advancing the development of novel therapies and diagnostic tools for cardio-cerebrovascular diseases.
Articles
A Protocol for Constructing a Mouse Model of Hypertensive Myocardial Fibrosis Using Angiotensin II
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2025
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Jinwen Wu*1, Hang Jiang*1, Xiaoyu Lan*1, Hanyu Hu1, Mingtai Chen2, Yuanyuan Li3,4, Gang Luo1, Qiuyu Liu5, Mengnan Liu1
1The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, 2Shenzhen Traditional Chinese Medicine Hospital, 3Guangdong-Macao In-Depth Cooperation Zone in Hengqin, Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), 4State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, 5School of Pharmacy, Southwest Medical University
Precision Ligation of the Left Anterior Descending Coronary Artery Using Anatomical Landmarks in a Murine Myocardial Infarction Model
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2026
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Linshen Mao*1,2, Houping Xu*1,2, Yan Wei*3, Li Dong1,2, Jinhui Jiang1,4, Qingyu Zhang1,4, Ping Liu1,4, Zhenzhou Li1,4, Mengnan Liu1,2, Gang Luo1,2
1Department of Cardiovascular Medicine, Affiliated Traditional Chinese Medicine Hospital, 2National Traditional Chinese Medicine Clinical Research Base, Affiliated Traditional Chinese Medicine Hospital, 3Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), 4School of Integrated Traditional and Western Medicine, Southwest Medical University