Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation. Over the past decade, it has emerged as a fundamental biological process with wide-ranging implications in cancer, neurodegeneration, ischemia-reperfusion injury, and immunology. Despite its growing importance, the field is limited by a lack of standardized methods and reproducible protocols that enable researchers to detect, induce, and modulate ferroptosis across different model systems.

This Methods Collection aims to assemble a set of practical, validated approaches for studying ferroptosis, spanning chemical and genetic tools, lipidomics workflows, cell-based assays, and in vivo models. By gathering diverse methodologies in a centralized resource, this collection will provide researchers with a toolkit to rigorously dissect ferroptosis mechanisms and apply them in biomedical contexts.

This collection will help the research community by promoting consistency, comparability, and innovation in ferroptosis research. It will also highlight emerging technologies that can accelerate translation of ferroptosis biology into therapeutic strategies, making it a valuable reference for established investigators and new entrants to the field.