The global demand for safer, more selective, and sustainable therapeutic strategies has accelerated interest in bio-inspired agents derived from natural and biologically engineered sources. These compounds offer tremendous potential for addressing complex diseases while minimizing adverse effects. Despite significant progress, the field continues to face challenges in standardizing experimental approaches, understanding molecular mechanisms, and translating preclinical findings into therapeutic applications.

This collection aims to serve as a comprehensive platform that encompasses methodological advances, original research, and reviews on natural and sustainable therapeutics. It welcomes detailed experimental protocols covering (but not limited to) extraction, purification, chemical and metabolomic profiling, cellular and molecular assays, mechanistic studies, and computational approaches. In addition, the collection encourages research articles that report discovery, characterization, and preclinical evaluation of bio-based therapeutics, including mechanistic insights, efficacy, pharmacokinetics, and safety assessments. Review articles that synthesize current knowledge, highlight emerging trends, and discuss future directions in the field will also be highlighted.

By bridging natural-product chemistry, molecular biology, pharmacology, and computational science, this collection aims to foster interdisciplinary collaboration, reproducibility, and innovation. It will serve as a valuable resource for researchers working on advancing green chemistry, drug discovery, and translational biomedical research, ultimately accelerating the development of next-generation therapeutics.