Drug Mechanisms and Clinical Effects in Modern Medicine: From Experimental Insights to Therapeutic Strategies

TOPICAL COLLECTIONS

Guest Editor

Vikas Kumar

Sam Higginbottom University of Agriculture, Technology & Sciences

Vikas Kumar is an Associate Professor of Pharmacognosy in the Department of Pharmaceutical Sciences at Sam Higginbottom University of Agriculture, Technology & Sciences. His research focuses on traditional medicines and natural product–based drug discovery, with an emphasis on identifying therapeutic leads for psoriasis, diabetes, cardiovascular diseases, and cancer. He has published more than 145 papers in high-impact journals, authored two books and twenty book chapters, and has earned over forty-five national and international awards. With an h-index of 42 and an i10-index of 130, Dr. Kumar has established himself as a significant contributor to the fields of pharmacognosy, phytochemistry, and nanomedicine in the context of disease prevention and therapy.

Collection Overview

Modern medicine is rapidly evolving through the integration of experimental pharmacology, molecular biology, and clinical sciences. Understanding drug mechanisms at the cellular and molecular level is crucial for developing safer and more effective therapeutic strategies. This Special Issue aims to bring together cutting-edge research and reviews that explore how pharmacological mechanisms translate from bench to bedside, highlighting novel therapeutic agents, clinical efficacy, safety profiles, and precision medicine approaches.

Articles

A Meta-Analysis of Exercise Intervention for Depression Symptoms

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2026

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Lina Duan¹, Yugang Chen²

¹School of Physical Education and Health Management, Lanzhou City University, ²The Third Department of General Surgery, Lanzhou Second People's Hospital

Comparative Outcomes of Meropenem and Imipenem in Multidrug-Resistant Pulmonary Infections: A Prospective Cohort Study

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2026

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Xue-Mei Jin¹, Jin Qiao¹, Fang Wang¹, Lei Bao¹, Zhong-Cheng Wang²

¹Department of Infection Management, Nantong Third People's Hospital / Affiliated Nantong Hospital 3 of Nantong University, ²Department of Integrated Traditional Chinese and Western Medicine Hepatology, Nantong Third People's Hospital / Affiliated Nantong Hospital 3 of Nantong University

Nicardipine Versus Nifedipine for Postpartum Hypertensive Emergencies in Severe Preeclampsia

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2026

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Huaqi Yao¹, Zhi Li², Lu Qian¹

¹Department of Intensive Care Medicine, Huzhou Maternity & Child Health Care Hospital, ²Department of Special Laboratory Examinations, Huzhou Maternity & Child Health Care Hospital

A Single Intravenous Dose of Indole-producing Attenuated <em>Brucella</em> in NOD Mice: Assessment of Type 1 Diabetes Onset and Islet Immune Remodeling

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A Single Intravenous Dose of Indole-producing Attenuated Brucella in NOD Mice: Assessment of Type 1 Diabetes Onset and Islet Immune Remodeling

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2026

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Kaylee Delgado*¹, Leslie G. Adams*², Paul de Figueiredo³, Jianxun Song¹

¹Department of Microbial Pathogenesis and Immunology, Texas A'M University Health Science Center, ²Department of Veterinary Pathobiology, College of Veterinary Medicine ' Biomedical Sciences, Texas A'M University, ³Bond Life Sciences Center, The University of Missouri

Nephroprotective Effects of Post-contrast N-Acetylcysteine and Montelukast Treatment in a Rat Model of Contrast-induced Acute Kidney Injury

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2026

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Yahya Şahin¹, Canan Şahin¹, Özlem Kara²

¹Department of Emergency Medicine, Kırşehir Ahi Evran University Faculty of Medicine, ²Department of Histology and Embryology, Kırşehir Ahi Evran University Faculty of Medicine

Nephroprotective Effects of Ethanol and Fomepizole in a Methotrexate-Pretreated Rat Model of Methanol Intoxication

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2026

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Yahya Şahin¹, Canan Şahin¹, Özlem Kara²

¹Department of Emergency Medicine, Ahi Evran University Faculty of Medicine, ²Department of Histology and Embryology, Kirsehir Ahi Evran University Faculty of Medicine

Abstracts

Association of Wenshen Antai Decoction Plus Low-Dose Aspirin with Live Birth in Unexplained Recurrent Pregnancy Loss: A Retrospective Cohort Study

Leilei Chen^*1

¹Wenzhou TCM Hospital of Zhejiang Chinese Medical University

Radiomics, Machine Learning, and Deep Learning for Differentiating Benign and Malignant Musculoskeletal Tumours: A Systematic Review and Meta-Analysis

Guanglin Wang^*1

¹West China Hospital

Indole-Producing Brucella Prevents Type 1 Diabetes by Reprogramming Islet Immunity

JIANXUN SONG^*1

¹Texas A&M University College of Medicine

Reducing Unnecessary Antibiotic Exposure in Late Preterm and Term Infants: A Two-Year Interrupted Time Series Quality Improvement Project

Yuan Wan^*1

¹Department of Neonatology, Xuancheng People’s Hospital

Intra-wound vancomycin powder for preventing surgical site infections in orthopedic surgery: a systematic review and meta-analysis

Liao Dengbin ^*1

¹Trauma Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China

Efficiency & safety of nafamostat mesylate injection clinical application in patients receiving continuous renal replacement therapy: a meta-analysis

Bingjie Yao ^*1

¹ICU, The Second Hospital of Jiaxing, Jiaxing, Zhejiang, 314000, China

Bergenin Triggers Apoptosis in Human Oral Squamous Cell Carcinoma KB Cells by Targeting the PI3K/Akt Pathway: A Biochemical and Molecular Study

Lixin Feng^*1

¹Anshan Central Hospital

Result Differences and Prognostic Analysis between mSOFA and SOFA Scoring Systems in Patients with Different Types of Shock

Ge Zhang^*1

¹, West China Longquan Hospital, Sichuan University (The First People's Hospital of Longquanyi District),

Hepatoprotective Effects of N-Acetylcysteine and Guarana in a Wistar Rat Model of Acute Acetaminophen Toxicity

CANAN SAHIN^*1

¹Ahi Evran University, Faculty of Medicine