Kidney stone disease, or nephrolithiasis, remains a significant global health concern with rising incidence due to changes in lifestyle, diet, and comorbid conditions such as obesity and diabetes. Despite advancements in diagnostic imaging and minimally invasive treatment techniques, kidney stones continue to impose a substantial clinical and economic burden worldwide. The condition not only causes severe pain and recurrent hospitalizations but also predisposes patients to chronic kidney disease, emphasizing the need for continuous innovation in both diagnostic and management strategies.

Several challenges persist in the field, including the early detection of asymptomatic stones, accurate prediction of recurrence risk, optimization of noninvasive treatment approaches, and personalized prevention strategies. In addition, understanding the complex biochemical and genetic factors driving stone formation remains incomplete, and current therapeutic modalities often fail to address the multifactorial nature of the disease.

This Collection aims to provide a comprehensive platform encompassing recent advances in diagnostic imaging, metabolic evaluation, medical and surgical management, and prevention strategies. It will include original research, clinical case reports, review articles, and methodological studies that collectively enhance understanding of kidney stone pathophysiology, detection, and treatment outcomes.

By consolidating interdisciplinary insights from urology, nephrology, radiology, and biochemistry, this collection will foster collaboration among clinicians and researchers, promote evidence-based clinical practice, and guide the development of next-generation diagnostic and therapeutic strategies for kidney stone disease.