Molecular and Cellular Mechanisms of Organ Injury and Repair

TOPICAL COLLECTIONS

Guest Editors

Jinzhen Cai

Organ Transplantation Center, The Affiliated Hospital of Qingdao University

Prof. Jinzhen Cai is a distinguished chief physician, professor, and doctoral supervisor, and serves as director of the Organ Transplantation Center at the Affiliated Hospital of Qingdao University. He is also dean of the Organ Donation and Transplantation Research Institute of Qingdao University and vice president of the hospital. In recognition of his outstanding contributions, Prof. Cai has been named a special allowance expert of Shandong Province and has received the People’s Outstanding Demeanor Award. He is actively involved in major professional organizations, including the Chinese Medical Association and the Chinese Association of Rehabilitation Medicine. In addition, he serves as a reviewer for leading SCI-indexed journals and as an editorial board member for several respected publications. His research focuses on organ transplantation, liver diseases, and ischemia–reperfusion injury, and has been supported by significant competitive funding, leading to multiple important advances in the field.

Xinqiang Li

Organ Transplantation Center, The Affiliated Hospital of Qingdao University

Dr. Xinqiang Li, MD–PhD, is a physician and researcher at the Organ Transplantation Center of the Affiliated Hospital of Qingdao University. His research focuses on liver injury repair, transplant immunology, and tumor immunology. Dr. Li serves as executive editor of Life Conflux, an editorial board member of Precision Medical Sciences, and a youth editorial board member for several journals. He is also a reviewer for multiple SCI-indexed journals. He has been invited to speak at national and international academic conferences, including CTC 2022, TTS 2024, CSOT 2024, TSS-Asian 2024, and APASL 2025.Dr. Li has received several honors and awards, including Outstanding Graduate of Shandong Province and the National PhD Scholarship. He has participated in three general projects of the National Natural Science Foundation of China, two general projects of the Shandong Provincial Natural Science Foundation, and one key project of the Fujian Provincial Natural Science Foundation.

Collection Overview

Organ injury resulting from infection, drug toxicity, trauma, or ischemia presents a fundamental challenge in clinical medicine. Understanding the balance between tissue damage and regenerative potential is crucial for developing effective therapeutics.

This Topical Collection focuses on the molecular and cellular mechanisms governing organ injury and repair across major systems, including the liver, kidney, and heart. We specifically invite contributions exploring regulated cell death pathways (e.g., ferroptosis, pyroptosis) and immune responses in various pathological contexts, ranging from toxic injury to ischemia-reperfusion and organ transplantation.

Given JoVE’s visual format, we emphasize reproducible protocols. We welcome submissions detailing surgical models of organ injury, advanced imaging of tissue regeneration, and molecular techniques for assessing cell survival. By integrating methods, reviews, and new results, this collection aims to provide a comprehensive resource to advance strategies that mitigate injury and restore organ function.