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TOPICAL COLLECTIONS

Integrating Real-World Evidence and Experimental Disease Models in Translational Medicine
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Guest Editors

Liang He

Liang He

Department of Urology, First Hospital of Jilin University

Liang He, MD, PhD, is an attending urologist in the Department of Urology at the First Hospital of Jilin University, China. He received his MD and PhD degrees from Jilin University and completed joint doctoral training at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. He later conducted postdoctoral research at Karolinska Institutet, focusing on tumor biology and translational medicine. His work centers on urologic oncology and nanomedicine, with an emphasis on multifunctional nanomaterials, image-guided therapy, and regulated cell death–based mechanisms, integrating fundamental mechanistic studies with translational research to advance precision therapeutic strategies for urologic malignancies.

Yan Jiao

Yan Jiao

Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jilin University

Yan Jiao, MD, PhD, is an attending physician in the Department of Hepatobiliary and Pancreatic Surgery at the First Hospital of Jilin University, China. He obtained his PhD from Jilin University and specializes in hepatobiliary and pancreatic diseases, with a strong focus on translational and data-driven clinical research. Dr. Jiao has extensive expertise in bioinformatics and large-scale public database mining, including NHANES, FAERS, and TCGA, applying advanced statistical and computational methods to investigate disease mechanisms, drug safety, and clinical outcomes. He has authored over 70 peer-reviewed publications spanning gastroenterology, oncology, surgery, and computational medicine, and actively contributes to methodological rigor and research integrity in biomedical science.

Chao Zheng

Chao Zheng

Department of Neurology, First Hospital of Jilin University

Dr. Chao Zheng, MD, PhD, is a neurologist and physician at the First Hospital of Jilin University, China. She obtained her PhD from the Karolinska Institutet, where she conducted research in neuroimmunology and glial biology. Dr. Zheng’s research focuses on neuroimmune diseases, with particular emphasis on multiple sclerosis. Her work centers on oligodendrocyte biology, neuroinflammatory mechanisms, and immune–glia interactions, integrating fundamental mechanistic studies with translational research to advance therapeutic strategies for immune-mediated neurological disorders.

Shenglin Chen

Shenglin Chen

Department of Hepatobiliary Surgery, Wuhu Hospital Affiliated to East China Normal University

Shenglin Chen, MD, MSc, is an associate chief physician and a member of the Youth Committee of the Wuhu Surgical Society as well as the Hepatobiliary and Pancreatic Surgery Committee of the Anhui Geriatrics Society. He received his master’s degree in surgery from Nanjing Medical University in 2014 and has since been engaged in clinical practice, teaching, and research in general surgery. In 2023, he completed advanced training at the First Affiliated Hospital of Guangzhou Medical University, focusing on percutaneous transhepatic one-stage biliary drainage and stone extraction for intrahepatic and extrahepatic bile duct stones. Dr. Chen has published multiple first-author papers in Scientific Reports, PLOS ONE, and the Journal of Surgical Research. His clinical expertise includes minimally invasive surgery for hepatobiliary–pancreatic, gastrointestinal, thyroid, hernia, and venous diseases.

Collection Overview

Human diseases are complex and heterogeneous, which makes reliable and clearly defined disease models essential for linking mechanistic research with clinical practice. Experimental and clinical disease models, ranging from in vitro systems and animal models to patient-derived samples, real-world clinical data, and case-based evidence, play an important role in understanding disease mechanisms, assessing therapeutic strategies, and supporting translational research.


This special collection aims to introduce visualized experimental and clinical disease models for a broad spectrum of biomedical fields. The collection will welcome JoVE video articles that clearly demonstrate the establishment, validation, and application of disease models, including experimental work, translational research pipelines, and clinical studies. Submissions describing well-documented clinical cases or case series that provide mechanistic or translational insights will also be encouraged, particularly when linked to experimental modeling or diagnostic approaches.


By clearly demonstrating experimental, clinical, and disease-modeling procedures, this collection serves as a practical educational resource for researchers and clinicians, supports communication across research fields, and helps bridge experimental work with clinical practice and patient care.

Articles

Artificial Intelligence for Predicting Secondary Complications and Clinical Outcomes in Traumatic Brain Injury: A Narrative Review

Artificial Intelligence for Predicting Secondary Complications and Clinical Outcomes in Traumatic Brain Injury: A Narrative Review

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2026

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Abstracts

Hypoxia-Driven Glycolytic Reprogramming in Pancreatic Ductal Adenocarcinoma: Molecular Mechanisms and Therapeutic Implications

Yan Jiao*1

1The First Hospital of Jilin University

Management of Soft-Tissue Defects from Bear Mauling: A Review of Reconstructive Strategies and Real-World Evidence

huanhuan She1

1Jilin university

Multimodal artificial intelligence for preventing anastomotic leakage after gastrointestinal surgery

Yan Jiao*1

1The First Hospital of Jilin University

Combined Vascular Resection in Pancreatic Cancer: Translational Evidence, Surgical Challenges, and Oncologic Implications

Yan Jiao*1

1The First Hospital of Jilin University

m6A methyltransferase METTL3 modification of FOXD1 to promote lung squamous cell carcinoma progression

Guangchao Lv*1

1The First Hospital of Jilin University,

Neuro-rhythmic uncoupling in diabetic gastroparesis

Yan Jiao*1

1The First Hospital of Jilin University

Beyond tumor resection: Gastrointestinal cancer surgery as metabolic reprogramming

Ying-Ying Xia1,

Dan Hou1,

Yan Jiao*1

1The First Hospital of Jilin University

Metabolic Regulatory Mechanisms of Angiogenesis in Pancreatic Cancer

Xin Ye1,

Ping Wang*1

1 The First Affiliated Hospital of Guangzhou Medical University

PGAM1 and Lymph Node Metastasis in Gastric Cancer: Clinical and Translational Perspectives

Yan Jiao*1

1The First Hospital of Jilin University

Association of thyroid disease and thyroid-stimulating hormone levels with gastrointestinal ulcers: evidence from NHANES 1999–2000

Yan Jiao*1

1first hospital of Jilin university

Chronobiology in gastroenterology: Circadian regulation of digestive diseases and therapeutic implications

Ying-Chao Wang*1

1The First Hospital of Jilin University

Surgery as metabolic therapy: Expanding the role of gastrointestinal surgery beyond anatomical reconstruction

Yan Jiao*1

1The First Hospital of Jilin University

Foundation Artificial Intelligence Models in Gastroenterology: Current Applications and Future Directions

Yan Jiao*1

1The First Hospital of Jilin University

Immunologic timing and therapeutic sequencing in hepatocellular carcinoma

Yan Jiao*1

1The First Hospital of Jilin University

Body composition as a determinant of treatment resilience after pancreaticoduodenectomy

Yan Jiao*1

1The First Hospital of Jilin University

Sepsis-Associated Gastrointestinal Dysfunction: Mechanisms and Clinical Implications

Yan Jiao*1

1The First Hospital of Jilin University

Filgotinib in Ulcerative Colitis: Long-term Outcomes and Treatment Positioning

Yan Jiao*1

1The First Hospital of Jilin University

Host Fitness in Gastrointestinal Oncology: Beyond Tumor Biology

Yan Jiao*1

1The First Hospital of Jilin University

From mutation detection to surgical decision-making: Recalibrating operative thresholds in pancreatic cystic lesions

Yan Jiao*1

1The First Hospital of Jilin University

Chrononutrition and Circadian Immunometabolism in Gastrointestinal Diseases: The Diet–Microbiome–Immune Axis and Therapeutic Opportunities

Yan Jiao*1

1The First Hospital of Jilin University

Oral-liver-pancreas axis in type two diabetes: Dysbiosis and beta-cell stress

Yan Jiao*1

1The First Hospital of Jilin University

Reconsidering anastomotic support to prevent biliary stricture after choledochojejunostomy

Yan Jiao*1

1The First Hospital of Jilin University

Percutaneous Transhepatic Cholangioscopy: Technical Evolution and Expanding Clinical Roles

Yan Jiao*1

1The First Hospital of Jilin University