

Liang He
Department of Urology, First Hospital of Jilin University
Liang He, MD, PhD, is an attending urologist in the Department of Urology at the First Hospital of Jilin University, China. He received his MD and PhD degrees from Jilin University and completed joint doctoral training at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences. He later conducted postdoctoral research at Karolinska Institutet, focusing on tumor biology and translational medicine. His work centers on urologic oncology and nanomedicine, with an emphasis on multifunctional nanomaterials, image-guided therapy, and regulated cell death–based mechanisms, integrating fundamental mechanistic studies with translational research to advance precision therapeutic strategies for urologic malignancies.

Yan Jiao
Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jilin University
Yan Jiao, MD, PhD, is an attending physician in the Department of Hepatobiliary and Pancreatic Surgery at the First Hospital of Jilin University, China. He obtained his PhD from Jilin University and specializes in hepatobiliary and pancreatic diseases, with a strong focus on translational and data-driven clinical research. Dr. Jiao has extensive expertise in bioinformatics and large-scale public database mining, including NHANES, FAERS, and TCGA, applying advanced statistical and computational methods to investigate disease mechanisms, drug safety, and clinical outcomes. He has authored over 70 peer-reviewed publications spanning gastroenterology, oncology, surgery, and computational medicine, and actively contributes to methodological rigor and research integrity in biomedical science.

Chao Zheng
Department of Neurology, First Hospital of Jilin University
Dr. Chao Zheng, MD, PhD, is a neurologist and physician at the First Hospital of Jilin University, China. She obtained her PhD from the Karolinska Institutet, where she conducted research in neuroimmunology and glial biology. Dr. Zheng’s research focuses on neuroimmune diseases, with particular emphasis on multiple sclerosis. Her work centers on oligodendrocyte biology, neuroinflammatory mechanisms, and immune–glia interactions, integrating fundamental mechanistic studies with translational research to advance therapeutic strategies for immune-mediated neurological disorders.

Shenglin Chen
Department of Hepatobiliary Surgery, Wuhu Hospital Affiliated to East China Normal University
Shenglin Chen, MD, MSc, is an associate chief physician and a member of the Youth Committee of the Wuhu Surgical Society as well as the Hepatobiliary and Pancreatic Surgery Committee of the Anhui Geriatrics Society. He received his master’s degree in surgery from Nanjing Medical University in 2014 and has since been engaged in clinical practice, teaching, and research in general surgery. In 2023, he completed advanced training at the First Affiliated Hospital of Guangzhou Medical University, focusing on percutaneous transhepatic one-stage biliary drainage and stone extraction for intrahepatic and extrahepatic bile duct stones. Dr. Chen has published multiple first-author papers in Scientific Reports, PLOS ONE, and the Journal of Surgical Research. His clinical expertise includes minimally invasive surgery for hepatobiliary–pancreatic, gastrointestinal, thyroid, hernia, and venous diseases.
Human diseases are complex and heterogeneous, which makes reliable and clearly defined disease models essential for linking mechanistic research with clinical practice. Experimental and clinical disease models, ranging from in vitro systems and animal models to patient-derived samples, real-world clinical data, and case-based evidence, play an important role in understanding disease mechanisms, assessing therapeutic strategies, and supporting translational research.
This special collection aims to introduce visualized experimental and clinical disease models for a broad spectrum of biomedical fields. The collection will welcome JoVE video articles that clearly demonstrate the establishment, validation, and application of disease models, including experimental work, translational research pipelines, and clinical studies. Submissions describing well-documented clinical cases or case series that provide mechanistic or translational insights will also be encouraged, particularly when linked to experimental modeling or diagnostic approaches.
By clearly demonstrating experimental, clinical, and disease-modeling procedures, this collection serves as a practical educational resource for researchers and clinicians, supports communication across research fields, and helps bridge experimental work with clinical practice and patient care.
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1Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangzhou Medical University, 2Department of Hepatobiliary Surgery, Nancheng Hospital (Hepatobiliary Hospital), 3Dongguan Institute of Gallbladder Disease Research, Nancheng Hospital (Hepatobiliary Hospital), 4Department of Nursing, Nancheng Hospital (Hepatobiliary Hospital)
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1Department of The First Operation Room, The First Hospital of Jilin University, 2Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, 3Department of Anesthesiology, Hospital of the Jilin Provincial Corps of the Chinese People's Armed Police Force
Hypoxia-Driven Glycolytic Reprogramming in Pancreatic Ductal Adenocarcinoma: Molecular Mechanisms and Therapeutic Implications
Yan Jiao*1
1The First Hospital of Jilin University
Management of Soft-Tissue Defects from Bear Mauling: A Review of Reconstructive Strategies and Real-World Evidence
huanhuan She1
1Jilin university
Multimodal artificial intelligence for preventing anastomotic leakage after gastrointestinal surgery
Yan Jiao*1
1The First Hospital of Jilin University
Combined Vascular Resection in Pancreatic Cancer: Translational Evidence, Surgical Challenges, and Oncologic Implications
Yan Jiao*1
1The First Hospital of Jilin University
m6A methyltransferase METTL3 modification of FOXD1 to promote lung squamous cell carcinoma progression
Guangchao Lv*1
1The First Hospital of Jilin University,
Neuro-rhythmic uncoupling in diabetic gastroparesis
Yan Jiao*1
1The First Hospital of Jilin University
Beyond tumor resection: Gastrointestinal cancer surgery as metabolic reprogramming
Ying-Ying Xia1,
Dan Hou1,
Yan Jiao*1
1The First Hospital of Jilin University
Metabolic Regulatory Mechanisms of Angiogenesis in Pancreatic Cancer
Xin Ye1,
Ping Wang*1
1 The First Affiliated Hospital of Guangzhou Medical University
PGAM1 and Lymph Node Metastasis in Gastric Cancer: Clinical and Translational Perspectives
Yan Jiao*1
1The First Hospital of Jilin University
Association of thyroid disease and thyroid-stimulating hormone levels with gastrointestinal ulcers: evidence from NHANES 1999–2000
Yan Jiao*1
1first hospital of Jilin university
Chronobiology in gastroenterology: Circadian regulation of digestive diseases and therapeutic implications
Ying-Chao Wang*1
1The First Hospital of Jilin University
Surgery as metabolic therapy: Expanding the role of gastrointestinal surgery beyond anatomical reconstruction
Yan Jiao*1
1The First Hospital of Jilin University
Foundation Artificial Intelligence Models in Gastroenterology: Current Applications and Future Directions
Yan Jiao*1
1The First Hospital of Jilin University
Immunologic timing and therapeutic sequencing in hepatocellular carcinoma
Yan Jiao*1
1The First Hospital of Jilin University
Body composition as a determinant of treatment resilience after pancreaticoduodenectomy
Yan Jiao*1
1The First Hospital of Jilin University
Sepsis-Associated Gastrointestinal Dysfunction: Mechanisms and Clinical Implications
Yan Jiao*1
1The First Hospital of Jilin University
Filgotinib in Ulcerative Colitis: Long-term Outcomes and Treatment Positioning
Yan Jiao*1
1The First Hospital of Jilin University
Host Fitness in Gastrointestinal Oncology: Beyond Tumor Biology
Yan Jiao*1
1The First Hospital of Jilin University
From mutation detection to surgical decision-making: Recalibrating operative thresholds in pancreatic cystic lesions
Yan Jiao*1
1The First Hospital of Jilin University
Chrononutrition and Circadian Immunometabolism in Gastrointestinal Diseases: The Diet–Microbiome–Immune Axis and Therapeutic Opportunities
Yan Jiao*1
1The First Hospital of Jilin University
Oral-liver-pancreas axis in type two diabetes: Dysbiosis and beta-cell stress
Yan Jiao*1
1The First Hospital of Jilin University
Reconsidering anastomotic support to prevent biliary stricture after choledochojejunostomy
Yan Jiao*1
1The First Hospital of Jilin University
Percutaneous Transhepatic Cholangioscopy: Technical Evolution and Expanding Clinical Roles
Yan Jiao*1
1The First Hospital of Jilin University