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TOPICAL COLLECTIONS

Confronting New Challenges in Oncology: Breakthrough Pathways in Precision Diagnosis and Effective Treatment
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Guest Editor

Jinghui Hong

Jinghui Hong

The First Hospital of Jilin University

Jinghui Hong, MD, is an attending physician and lecturer at The First Hospital of Jilin University, and also serves as an honorary research associate at the University of Bristol, UK. His work bridges clinical practice and translational research in oncology, with a focus on addressing critical challenges in cancer treatment. Dr. Hong's primary research centers on the mechanisms of tumor drug resistance, a major obstacle to effective cancer therapy. His investigations explore the molecular and cellular adaptations that enable cancer cells to evade chemotherapy, targeted therapy, and immunotherapy. Utilizing a multidisciplinary approach that includes in vitro models, patient-derived samples, and bioinformatic analyses, he aims to identify novel biomarkers of resistance and uncover actionable therapeutic targets to overcome treatment resistance. Ultimately, his work strives to translate these discoveries into clinically applicable strategies to improve outcomes for patients with refractory or relapsed cancers. Committed to collaborative and interdisciplinary science, Dr. Hong is dedicated to advancing oncology research in ways that directly address unmet needs in clinical practice.

Collection Overview

Tumor heterogeneity and drug resistance remain central challenges in modern clinical oncology, underscoring the urgent need for precision diagnostics and more effective therapeutic strategies to improve patient outcomes. This collection systematically highlights recent advances in cutting-edge diagnostic technologies, such as liquid biopsy and molecular imaging; refined prognostic prediction approaches, including bioinformatics-driven analyses and well-curated clinical cohort studies; and innovative therapeutic modalities encompassing targeted therapies, immunomodulatory strategies, and rational combination treatments. By integrating multidisciplinary methodologies, the collection aims to accelerate the translation of basic research discoveries into clinical applications. It will provide critical insights for both researchers and clinicians, support the optimization of personalized treatment regimens, and facilitate the rapid clinical adoption of breakthrough advances in cancer diagnosis and therapy.

Articles

S100P as a Shared Biomarker in Inflammatory Bowel Disease, Colorectal Cancer, and Pancreatic Adenocarcinoma: An Integrated Transcriptomic Analysis

S100P as a Shared Biomarker in Inflammatory Bowel Disease, Colorectal Cancer, and Pancreatic Adenocarcinoma: An Integrated Transcriptomic Analysis

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2026

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Abstracts

Integrative Pan-Cancer Multi-Omics Analysis Identifies KRT81 as a Diagnostic, Prognostic, and Immunotherapeutic Biomarker

Tong Liu*1

1 Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine

A Bioinformatics Framework for Developing a Cancer-Associated Fibroblast Prognostic Signature in Glioma

Yong Wang*1

1Yanbian University Hospital

Multi-omics Integration Reveals the Diagnostic Value of THBS2 and Its Role in Microenvironmental Remodeling in OLP and OSCC

Liyuan Wang1

1General Hospital of Ningxia Medical University

From Tumor Suppressor to Tumor Promoter – The Dual Role of LIMCH1 in Cancer and Its Clinical Implications

Ying Li1

1Jilin Medical University

Integrated multi-omics investigation of the ferro-aging pathway in glioblastoma

Huiying Li*1

1Beihua University