Microvascular and endothelial dysfunction are central mechanisms underlying the development and progression of both chronic and infectious diseases. Alterations in microcirculation contribute to impaired tissue perfusion, inflammation, and organ dysfunction in conditions such as diabetes, obesity, dyslipidemia, cancer, and systemic infections, making the microvasculature a critical therapeutic target in cardiovascular pharmacology.

This Topical Collection aims to highlight experimental and translational approaches that advance the understanding of microvascular and endothelial dysfunction across diverse disease contexts. By focusing on pharmacological modulation of endothelial and microvascular pathways, the collection seeks to integrate mechanistic insights with functional and methodological perspectives relevant to cardiovascular and vascular research.

By including in vivo, intravital, and functional microvascular assessments, this collection will provide the research community with a rigorous, methodologically grounded overview of current strategies for studying and targeting microvascular dysfunction in chronic and infectious diseases.