Lymphedema, a chronic and often progressive disorder of lymphatic insufficiency, is a global health concern that impairs quality of life and predisposes affected individuals to infection, inflammation, and metabolic disturbances. Emerging evidence indicates that nutritional status may profoundly influence the onset, progression, and management of lymphedema through mechanisms involving inflammation, oxidative stress, adipose remodeling, and microvascular integrity. This Special Issue brings together methodological advances and clinical models exploring how targeted nutritional interventions, including lessons from microvasculature maintenance, can modify lymphatic function and tissue homeostasis. We seek clinical and preclinical contributions that demonstrate techniques for improving lymphatic flow, assessing and reducing inflammatory biomarkers, and regulating metabolic crosstalk. The featured articles aim to standardize reproducible methods for studying the nutrition, lymphatic axis and to promote translational strategies for preventing and managing lymphedema. This issue underscores the need for interdisciplinary approaches linking nutrition science, vascular biology, and rehabilitation medicine to inform integrative lymphatic care.