Trauma is the leading cause of death and disability in young adults. Rapid exsanguination accompanied by shock majorly contributes to mortality after traumatic injury. Even though there are improved protocols including fluid resuscitation and transfusion strategies, the mortality rate due to trauma remains high. Acute traumatic coagulopathy (ATC) is a major complication of traumatic bleeding, and occurs within the first few hours of trauma. About 30% of patients tend to develop ATC, contributing to uncontrolled bleeding with high mortality rates. The lethal triad of trauma – ATC in association with coagulopathy, hypothermia, and acidosis, contributes to this vicious cycle. Advances in management of ATC remain limited due to optimization of goal-directed blood component transfusion strategies and tranexamic acid (TXA). Early treatment with TXA has resulted in reduction of bleeding and mortality rate; however, it requires further improvement. Currently, there are insufficient models and treatment modalities to study and explore ATC. Thus, the scientific community will greatly benefit from this method collection, where there is a single platform for all the methodologies and treatment modalities of traumatic injury. 

The goals of this method collection are: (1) to provide state-of the-art protocols and procedures for the induction of trauma or polytrauma in various animal models, (2) to introduce novel approaches in treatment modalities, such as usage of anti-fibrinolytic agents or the of recombinant factor products, and (3) to understand the molecular mechanisms of trauma induced coagulopathy.