Als Patients

ALS patients are individuals living with amyotrophic lateral sclerosis, a progressive neurodegenerative disease that damages motor neurons and affects movement, communication, and daily behavior. As upper and lower motor neurons deteriorate, patients may experience muscle weakness alongside changes in emotional expression, executive function, social conduct, or decision-making, although behavioral effects vary widely. Studying these changes helps clinicians distinguish neurological symptoms from understandable psychological responses to disability and supports comprehensive assessment. Behavioral evaluation can guide communication strategies, caregiver support, safety planning, and personalized care, while also improving research on ALS progression and the overlap between motor neuron disease and frontotemporal disorders.

Als Patients - Related Videos

Research

JoVE Journal - Neuroscience
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Transcranial Pulse Stimulation for Alzheimer's Patients

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2025

This article describes the procedure of transcranial pulse stimulation in patients with Alzheimer's disease. It discusses the indications, methodology, and future prospects in detail.

Education

JoVE Science Education - Clinical Skills

Proper Adjustment of Patient Attire during the Physical Exam

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2023

Source: Jaideep S. Talwalkar, MD, and Joseph Donroe, MD, Internal Medicine and Pediatrics, Yale School of Medicine, New Haven, CT In order to optimize the predictive value of the physical examination, the provider must perform maneuvers correctly. The proper use of drapes is an important component of correctly performing physical examination maneuvers. Skin lesions are missed when "inspection" occurs through clothing, crackles are erroneously reported when the lungs are examined through a...

Establishment and Culture of Patient-Derived Breast Organoids

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Cited by 11 •

2023

A detailed protocol is provided here for establishing human breast organoids from patient-derived breast tumor resections or normal breast tissue. The protocol provides comprehensive step-by-step instructions for culturing, freezing, and thawing human patient-derived breast organoids.

Research

JoVE Journal - Medicine
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Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

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Cited by 5 •

2024

Corneal sensitivity testing provides insight into the health of the corneal nerves and helps diagnose ocular surface diseases. We present a concise protocol to qualitatively assess corneal sensitivity that can be readily used by eye care providers across clinical settings.

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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Cited by 10 •

2017

This protocol was developed to quantitatively identify tumor microenvironment components in glioblastoma patient resections using chromogenic immunohistochemistry and ImageJ.

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