Flow Loop Apparatus
Flow Loop Apparatus - Related Videos
09:22
Quantitatively Measuring In situ Flows using a Self-Contained Underwater Velocimetry Apparatus (SCUVA)
0 Views •
Cited by 6 •
2011
This protocol provides instructions on how to use a self-contained underwater velocimetry apparatus (SCUVA), which is designed for quantification of in situ animal-generated flows. In addition, this protocol addresses challenges posed by field conditions, and includes operator motion, predicting position of animals, and orientation of SCUVA.
06:16
Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model
0 Views •
2024
In-vitro thrombolysis assays have often struggled to replicate in-vivo conditions whether in the model thrombus being digested or in the environment in which thrombolysis is occurring. Herein, we explore how coupling the Chandler loop and Real-Time Fluorometric Flowing Fibrinolysis Assay (RT-FluFF) is used for high-fidelity, ex-vivo, clot lysis monitoring.
10:15
The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
0 Views •
Cited by 17 •
2014
Blood exposure to polymeric blood conduits initiates the foreign body reaction that has been implicated in clinical complications. Here, the Chandler Loop Apparatus, an experimental tool mimicking blood perfusion through these conduits, is described. Appendage of recombinant CD47 results in decreased evidence of the foreign body reaction on these conduits.
07:32
Novel Apparatus and Method for Drug Reinforcement
0 Views •
Cited by 9 •
2010
Operant drug self-administration and conditioned place preference (CPP) procedures are expansively used in research to model various components of drug reinforcement, consumption, and addiction in humans. In this report, we combined traditional CPP and self-administration methods as a novel approach to studying drug reinforcement and addiction in rats.
17:15
Catheterization of Intestinal Loops in Ruminants
0 Views •
Cited by 4 •
2009
We describe a novel surgical method for catheterizing 'intestinal loops' within the ileum of sheep. Once animals have recovered from surgery and have cleared antibiotics and analgesics, multiple treatments can be deposited directly in loops via the catheters.
FAQs
The pump provides the driving force, moving fluid from the reservoir through the tubing and test section before it returns through the circuit. The test section contains the device or material under evaluation, while measurement devices record conditions during circulation. This arrangement creates a repeatable path for examining transport behavior and device performance under controlled flow.
Adjustable resistance changes how readily fluid moves through the circuit, allowing researchers to establish selected pressure and flow conditions. Controlling these variables helps reproduce defined loading rather than relying on an uncontrolled stream. The resulting conditions can be tailored to evaluate how a biomedical device or engineered material responds to fluid movement relevant to bioengineering studies.
Pressure and flow measurements show how fluid conditions change as the circuit operates and how the tested component influences that behavior. Comparing these measurements under defined settings supports analysis of transport and fluid behavior, while also revealing performance characteristics that may affect device design. Together, the data provide an experimental basis for evaluating interactions with biological fluids.
Researchers place the test component in the circuit, fill the system from the reservoir, and use the pump to circulate fluid through the tubing and test section. They then adjust resistance, pressure, or flow rate to establish the intended condition and collect measurements during operation. This workflow produces pressure and flow data for subsequent performance analysis.
Flow loops support testing of vascular grafts, catheters, tissue-engineered vessels, and other biomedical devices exposed to moving fluid. The device is positioned in the test section, where controlled circulation provides a defined loading environment. Researchers can then examine performance under conditions designed to represent physiologically relevant flow, helping compare designs or assess suitability for further development.
Measured pressure and flow data help researchers determine how a device or engineered material behaves within a circulating biological-fluid environment. These results can inform design decisions, performance testing, and interpretation of fluid-material interactions. In bioengineering, the approach connects controlled laboratory measurements with questions about how vascular or other fluid-contacting constructs function under loading.