Foster Mothers
Foster Mothers - Related Videos
05:04
A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
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2023
Here, we present a nonhuman primate model of mother-infant intervention for breastfeeding disorders in the presence of paternal inhibition and maternal neglect. The mate model video complements education to support primate and human caregivers with respect to infants with breastfeeding problems such as pain.
01:37
A Preterm Rat Model for Pain Studies
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2024
Here, we present a concise protocol for creating a preterm rat model, facilitating research on early postnatal pain management. The method involves performing a cesarean section three days before the expected birth, extracting preterm rat pups via hysterectomy, and integrating them with the biological offspring of a surrogate dam.
06:39
Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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2021
The chronic psychosocial stress (CGS) paradigm employs clinically relevant stressors during pregnancy in mice to model psychiatric disorders of mothers and infants. Here, we provide a step-by-step procedure of applying the CGS paradigm and downstream assessments to validate this model.
07:48
Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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Cited by 37 •
2016
This protocol describes a highly reproducible model of cardiac regeneration by surgical induction of myocardial infarction in the left ventricle of postnatal day 1 mice. The method involves induction of hypothermic anesthesia and ligation of the left anterior descending coronary artery.
11:08
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
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Cited by 11 •
2014
Mutation rates in young Saccharomyces cerevisiae cells measured through fluctuation tests are used to predict mutation frequencies for mother cells of different replicative ages. Magnetic sorting and flow cytometry are then used to measure actual mutation frequencies and age of mother cells to identify any deviations from predicted mutation frequencies.
FAQs
Successful fostering depends primarily on physiological compatibility between the female and the transferred embryo or newborn, together with acceptance of the offspring. The foster mother must provide an environment capable of supporting the relevant developmental needs, including pregnancy, lactation, thermoregulation, and caregiving. When these conditions align, they improve the likelihood of survival and continued maturation.
These maternal functions support offspring in complementary ways. Pregnancy provides the developmental environment for transferred embryos, while lactation supplies nourishment after birth. Thermoregulation helps maintain suitable body conditions, and caregiving supports continued rearing. Consequently, the requirements placed on a foster mother depend on whether researchers transfer an embryo or a newborn.
Physiological compatibility alone may not provide the complete maternal environment required for development. The foster mother must also accept the offspring so that caregiving can occur after transfer. Acceptance therefore links the female's biological capacity with her behavioral response, helping create conditions in which the offspring can survive, mature, and remain integrated into the rearing environment.
A study transfers an embryo or newborn to a suitable female, then relies on her pregnancy, lactation, thermoregulation, or caregiving to support development, depending on the offspring's stage. Researchers assess whether the female accepts the offspring and whether survival and maturation proceed. This workflow connects reproductive support with the later study of the engineered organism.
Foster mothers are useful when a biological mother is unavailable or cannot support development, including work with genetically altered animals. They help researchers maintain engineered animal lines and evaluate genetic modifications by providing maternal support to transferred embryos or newborns. This makes fostering a practical link between reproductive biology and the production of animals for research.
By supporting the survival and maturation of transferred offspring, foster mothers help researchers produce organisms carrying engineered genetic changes. Those organisms can then be used in disease modeling or biotechnology studies. The approach is valuable because maternal support enables development of the animals needed to examine genetic modifications and their relevance to experimental or applied research.