Heart Pacing

Heart pacing is the controlled application of electrical stimulation to the heart to initiate or regulate cardiac contractions when its natural rhythm is impaired. A pacing device or electrode delivers timed electrical pulses that depolarize cardiac muscle, triggering coordinated contraction and supporting an appropriate heart rate. In bioengineering, heart pacing underpins the design of pacemakers, cardiac monitoring systems, and engineered heart tissues used to study electrical conduction and arrhythmias. These approaches help restore circulation in patients with rhythm disorders while enabling researchers to evaluate cardiac function, test therapies, and develop more responsive implantable devices.

Heart Pacing - Related Videos

Research

JoVE Journal - Biology

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

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2023

The present protocol describes obtaining the pressure-volume relationship through transesophageal pacing, which serves as a valuable tool in evaluating diastolic function in mouse models of heart failure.

Research

JoVE Journal - Medicine
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Translational Rabbit Model of Chronic Cardiac Pacing

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2023

We present a minimally invasive leporine model of long-term cardiac pacing that can be utilized for artificial pacing and heart failure development in preclinical studies.

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

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Cited by 6 •

2022

The present work describes an experimental protocol of transesophageal atrial burst pacing for efficient induction of atrial fibrillation (AF) in rats. The protocol can be used in rats with healthy or remodeled hearts, allowing the study of AF pathophysiology, identification of novel therapeutic targets, and evaluation of new therapeutic strategies.

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice

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Cited by 3 •

2022

The present protocol describes the optimization of experimental parameters when using transesophageal atrial pacing to assess atrial fibrillation susceptibility in mice.

A Novel Ex vivo Culture Method for the Embryonic Mouse Heart

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Cited by 10 •

2013

Developmental studies in the mouse are hampered by the inaccessibility of the embryo during gestation. To promote the long-term culture of the embryonic heart at late stages of gestation, we developed a protocol in which the excised heart is cultured in a semi-solid, dilute Matrigel.

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