Patient-specific Lung Models
Patient-specific Lung Models - Related Videos
07:56
Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models
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Cited by 9 •
2020
We present a high-throughput, in vitro method for quantifying regional pulmonary deposition at the lobe level using CT scan-derived, 3D printed lung models with tunable air flow profiles.
12:09
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
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Cited by 14 •
2013
A methodology to estimate ventricular fiber orientations from in vivo images of patient heart geometries for personalized modeling is described. Validation of the methodology performed using normal and failing canine hearts demonstrate that that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.
09:15
Creation of Patient-Specific Silicone Cardiac Models with Applications in Pre-surgical Plans and Hands-on Training
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Cited by 10 •
2022
Patient-specific models improve surgeon and fellow confidence when developing or learning surgical plans. Three-dimensional (3D) printers generate adequate detail for surgical preparation, but fail to replicate tissue haptic fidelity. A protocol is presented detailing the creation of patient-specific, silicone cardiac models, combining 3D printing precision with simulated silicone tissue.
05:25
Dissection and Isolation of Region-Specific Decellularized Lung Tissue
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2023
Presented here is a protocol for the isolation of regional decellularized lung tissue. This protocol provides a powerful tool for studying complexities in the extracellular matrix and cell-matrix interactions.
07:30
3D Printing Model of a Patient's Specific Lumbar Vertebra
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Cited by 4 •
2023
This study aims to create a 3D-printed model of a patient-specific lumbar vertebra, which contains both the vertebra and spinal nerve models fused from high-resolution computed tomography (HRCT) and MRI-Dixon data.
FAQs
Patient-derived cells or tissues preserve features associated with an individual’s biology, allowing the model to reflect disease characteristics or treatment responses more closely than a generic system. When these materials are combined with three-dimensional culture platforms, researchers can examine how patient-specific traits influence lung behavior. This supports investigations that may be less representative in conventional cell cultures.
Air-liquid interfaces and mechanical breathing forces recreate key conditions that lung cells experience in the body. Including these features can make the laboratory environment more representative of lung function than a static culture system. Their incorporation helps researchers study cell behavior and disease features under conditions that better reflect the physical context relevant to pulmonary bioengineering.
Because the systems can incorporate patient-derived biological material and controlled lung conditions, researchers can compare how individual genetic or environmental differences affect disease features or treatment responses. This comparison helps separate responses that are broadly shared from those that vary between individuals. The resulting information can guide more representative biomedical studies and support treatment strategies tailored to patient variability.
Development generally involves selecting patient-derived cells or tissues, placing them in a suitable three-dimensional culture platform, and adding biomaterials, organoids, or microfluidic devices as needed. Researchers then reproduce relevant lung conditions, including an air-liquid interface or mechanical breathing forces. The completed system can be evaluated for disease features, cell behavior, or responses to an experimental treatment.
Researchers may choose these models when conventional cell cultures do not adequately represent an individual’s disease features or likely treatment response. Their three-dimensional organization and patient-derived components can provide a more representative setting for studying disease mechanisms and evaluating therapies. They also complement, rather than simply replace, conventional cultures and animal studies during biomedical research.
Patient-specific Lung Models can be used to evaluate how an individual’s lung tissue responds to potential treatments, helping researchers investigate differences in efficacy or response patterns. This information contributes to personalized medicine by connecting experimental findings with patient-specific biology. The models also support development of safer, more effective therapies and can inform regenerative engineering research.