Aging Mouse Models
Aging Mouse Models - Related Videos
06:58
Frailty Assessment in an Aging Mouse Model
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2025
The goal of the present protocol is to provide instructions and guidelines for assessing physical frailty in C57Bl/6x129J laboratory mice. Specific details regarding each measure used in the physical frailty index are explained. Several methods for reporting frailty results are also presented.
09:30
Behavioral Assessment of the Aging Mouse Vestibular System
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Cited by 48 •
2014
Motor control and balance performance are known to deteriorate with age. This paper presents a number of standard noninvasive behavioral tests with the addition of a simple rotary stimulus to challenge the vestibular system and show changes in balance performance in a murine model of aging.
12:21
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
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Cited by 3 •
2022
This paper describes a novel mouse model for the transition of pneumococcus from an asymptomatic colonizer to a disease-causing pathogen during viral infection. This model can be readily adapted to study polymicrobial and host-pathogen interactions during the different phases of disease progression and across various hosts.
09:24
A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration
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Cited by 1 •
2023
Mouse models can be useful tools for investigating the biology of the retinal pigmented epithelium (RPE). It has been established that mice can develop an array of RPE pathologies. Here, we describe a phenotyping protocol to elucidate and quantify RPE pathologies in mice using light, transmission electron, and confocal microscopy.
10:24
Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
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Cited by 13 •
2014
Indocyanine Green Angiography (or ICGA) performed by tail vein injection provides high quality ICGA time course images to characterize abnormalities in mouse choroid.
FAQs
Model choice determines which aspect of aging researchers can examine. Naturally aged mice capture changes that emerge over time, whereas progeroid models represent accelerated aging-related processes. Genetically modified mice allow investigators to focus on particular biological mechanisms, and experimental interventions can probe pathways directly. Comparing these designs helps distinguish general aging features from effects tied to a specific alteration.
Several interacting processes can shape age-related phenotypes in these models. Cellular senescence concerns cells that stop dividing, while DNA damage responses reflect how cells react to genomic injury. Inflammation and metabolic regulation add further dimensions. Studying these pathways across tissues can reveal whether a change is localized or part of a broader biological pattern associated with aging.
A useful comparison is between healthy aging and disease progression. Researchers can examine whether tissue changes arise as part of ordinary aging or accompany conditions such as neurodegeneration, cancer, or cardiovascular disease. This distinction matters because a model may illuminate an aging mechanism without reproducing every feature of a particular disease, helping investigators interpret findings with appropriate scope.
Studies commonly begin by selecting naturally aged, progeroid, or genetically modified mice according to the biological question. Investigators then examine changes across tissues, assess pathways or phenotypes of interest, and may test an experimental intervention. Comparing model types or intervention conditions can show whether a treatment changes an aging-related process or a disease-associated outcome.
These models can support investigations related to longevity, tissue changes, and disease-associated biology. Their value lies not only in detecting whether an intervention has an effect, but also in linking that effect to processes such as senescence, DNA damage responses, inflammation, or metabolic regulation. Such links help researchers evaluate mechanisms rather than relying solely on an observable outcome.
Researchers apply Aging Mouse Models across several biological problems, including neurodegeneration, cancer, cardiovascular disease, and regenerative biology. The same broad strategy can therefore address both deterioration and tissue repair. Studying multiple disease contexts helps reveal which aging-related mechanisms are shared across conditions and which are more closely associated with a particular organ system or biological outcome.
Findings from mouse studies require attention to how closely the experimental system reflects human health. Researchers use these models to evaluate that relevance while considering whether observed mechanisms, tissue changes, or intervention effects correspond to human aging or disease. This translational question is especially important when a model uses accelerated aging or a targeted genetic alteration rather than natural aging.