Noise Function Application

Noise function application is the use of mathematical functions that generate controlled, often spatially correlated variation to represent irregular biological patterns. Unlike purely random values, noise functions calculate outputs from coordinates, using interpolation and parameters such as scale, amplitude, and frequency to produce smooth or multiscale changes. In biology, these functions can model heterogeneous environments, simulate tissue or organismal patterns, create realistic visualizations, and introduce reproducible variability into computational experiments. By adjusting the function and its parameters, researchers can test how spatial structure influences biological systems while maintaining control over the modeled conditions.

Noise Function Application - Related Videos

Research

JoVE Journal - Neuroscience

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

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2023

Here, we present a protocol for a mouse model of noise-induced hearing loss (NIHL). To induce NIHL, we developed a new and simple device using corrugated plastic, a rat trap cage, and a speaker. Auditory brainstem response and immunofluorescence imaging were employed to assess the hearing function and outer hair cell damage, respectively.

Stochastic Noise Application for the Assessment of Medial Vestibular Nucleus Neuron Sensitivity In Vitro

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Cited by 5 •

2019

Galvanic vestibular stimulation in humans exhibits improvements in vestibular function. However, it is unknown how these effects occur. Here, we describe how to apply sinusoidal and stochastic electrical noise and evaluate appropriate stimulus amplitudes in individual medial vestibular nucleus neurons in the C57BL/6 mouse.

Research

JoVE Journal - Engineering
Free Sample

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

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Cited by 18 •

2013

A methodology for preparing solid-state nanopores in solution for biomolecular translocation experiments is presented. By applying short pulses of high electric fields, the nanopore diameter can be controllably enlarged with subnanometer precision and its electrical noise characteristics significantly improved. This procedure is performed in situ using standard laboratory equipment under experimental conditions.

Continuous Monitoring of Biological Noise in Bacteria Using Time-Lapse Microscopy

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2025

Source: Chaimovitz, E. A., et al. Continuous Measurement of Biological Noise in Escherichia Coli Using Time-lapse Microscopy. J. Vis. Exp. (2021)This video demonstrates real-time visualization of biological noise in E. coli by tracking fluctuations in GFP fluorescence during bacterial growth and division using time-lapse microscopy.

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

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Cited by 17 •

2016

We present a protocol for the synthesis of RGD-functionalized hydrogels as devices for cell and drug delivery. The procedure involves copper catalyzed alkyne-azide cycloaddition (CuAAC) between alkyne-modified polyacrylic acid (PAA) and a RGD-azide derivative. The hydrogels are formed using microwave-assisted polycondensation and their physicochemical properties are investigated.

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