Single Crystal
Single Crystal - Related Videos
08:14
Single Crystal and Powder X-ray Diffraction
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2023
Source: Tamara M. Powers, Department of Chemistry, Texas A&M University X-ray crystallography is a technique that uses X-rays to study the structure of molecules. X-ray diffraction (XRD) experiments are routinely carried out with either single-crystal or powdered samples. Single-crystal XRD: Single-crystal XRD allows for absolute structure determination. With single-crystal XRD data, the exact atomic positions can be observed, and thus bond lengths and angles can be determined. This...
04:51
Comparison of Two Different Synthesis Methods of Single Crystals of Superconducting Uranium Ditelluride
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Cited by 13 •
2021
Here, we present a protocol to synthesize two types of UTe2 crystals: those exhibiting robust superconductivity, via chemical vapor transport synthesis, and those lacking superconductivity, via molten metal flux synthesis.
06:19
High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
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Cited by 14 •
2023
This protocol details high-throughput crystallization screening, ranging from the 1,536 microassay plate preparation to the end of a 6 week experimental time window. Details are included about the sample setup, the imaging obtained, and how users can perform analyses using an artificial intelligence-enabled graphical user interface to quickly and efficiently identify macromolecular crystallization conditions.
08:43
Effect of Bending on the Electrical Characteristics of Flexible Organic Single Crystal-based Field-effect Transistors
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Cited by 1 •
2016
This manuscript describes the bending process of an organic single crystal-based field-effect transistor to maintain a functioning device for electronic property measurement. The results suggest that bending causes changes in the molecular spacing in the crystal and thus in the charge hopping rate, which is important in flexible electronics.
07:08
Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization
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Cited by 5 •
2015
This is a quick, cost-efficient protocol for the production of secreted, glycosylated mammalian proteins and subsequent single-step purification with sufficient yields of homogenous protein for X-ray crystallography and other biophysical studies.
FAQs
A crystal's ordered lattice causes X-rays to diffract in defined directions rather than producing an uninterpreted pattern. Those directions contain information about the arrangement of atoms, ions, or molecules within the solid. Chemists use the resulting structural information to examine molecular and solid-state structures, including how bonding and symmetry are expressed in the crystallized material.
These changes alter the conditions under which particles arrange into repeating patterns. If crystallization proceeds in a controlled way, one continuous lattice can develop; if separate crystal domains form, structural uniformity is lost. Controlling how the solid emerges is therefore central to obtaining a specimen suitable for precise structural analysis and limiting competing crystal growth.
Single-crystal studies let chemists investigate more than overall composition. The ordered solid provides a basis for examining bonding and symmetry, while comparisons among crystal forms can address polymorphism, meaning the occurrence of different solid forms. Analysis can also reveal defects in the lattice. These questions connect microscopic arrangement with the properties of molecular and solid-state materials.
To obtain a usable specimen, chemists promote crystallization by cooling a system, allowing solvent to evaporate, or changing solvent composition. The conditions are controlled so particles assemble into one lattice rather than multiple crystal domains. The resulting crystal can then be examined by X-ray diffraction, linking the preparation step directly to structural determination.
Chemists choose a single crystal when they need precise structural information about a material. It is especially useful for investigating molecular or solid-state structure, bonding, symmetry, polymorphism, and defects. This makes the approach relevant when structure and material properties must be considered together, including studies of compounds being examined for functional or applied uses.
In chemistry, single-crystal analysis supports work on pharmaceuticals, catalysts, electronic materials, and other functional compounds. Determining the ordered arrangement helps researchers characterize the solid and relate its structure to material properties. The same structural perspective can distinguish polymorphic forms and identify defects, making crystallography valuable for understanding compounds and developing materials with targeted functions.