Skeletal Model
Skeletal Model - Related Videos
05:58
Tissue Triage and Freezing for Models of Skeletal Muscle Disease
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Cited by 97 •
2014
The analysis of skeletal muscle tissues to determine structural, functional, and biochemical properties is greatly facilitated by appropriate preparation. This protocol describes appropriate methods to prepare skeletal muscle tissue for a broad range of phenotyping studies.
10:50
Tibial Nerve Transection - A Standardized Model for Denervation-induced Skeletal Muscle Atrophy in Mice
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Cited by 38 •
2013
The tibial nerve transection model is a well-tolerated, validated, and reproducible model of skeletal muscle atrophy. The model surgical protocol is described and demonstrated in C57Black6 mice.
09:14
Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
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Cited by 15 •
2017
Here we present a detailed protocol to detect both senescent and pluripotent stem cells in the skeletal muscle upon injury while inducing in vivo reprogramming. This method is suitable for evaluating the role of cellular senescence during tissue regeneration and reprogramming in vivo.
07:29
A Cryoinjury Model for Studying Skeletal Muscle Regeneration of the Caudal Peduncle in Adult Zebrafish
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Cited by 2 •
2023
This protocol describes a cryoinjury model to induce profound damage of several caudal myomeres in adult zebrafish. This method provides a new approach for studying skeletal muscle regeneration after severe loss of tissue in non-mammalian vertebrates.
09:45
Mitochondrial Isolation from Skeletal Muscle
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Cited by 48 •
2011
This protocol describes a procedure to study the respiration of mitochondria isolated from skeletal muscles. This method was adapted from Scorrano et al. (2007). The mitochondrial isolation procedure requires about 2 hours. The mitochondrial respiration can be completed in about 1 hour.
FAQs
Follow each line from one vertex or line end to the next to reconstruct the carbon connectivity. Because attached hydrogens are not written, the drawing emphasizes the framework rather than every atom label. Explicit oxygen or nitrogen atoms interrupt this carbon-only shorthand and identify where heteroatoms contribute to the molecular structure.
Writing oxygen, nitrogen, and other heteroatoms directly distinguishes chemically important sites from the implied carbon framework. Their positions help reveal functional groups and clarify how different parts of an organic molecule are connected. This makes the representation more useful for interpreting reactivity, comparing structures, and following changes in a reaction pathway.
It allows chemists to compare how the same types of atoms are connected rather than relying only on a molecular formula. A change in the arrangement of the carbon framework or in the position of a functional group becomes visible in the drawing. This supports identification and discussion of structural isomers with different connectivities.
A skeletal model can preserve structural information needed to analyze stereochemistry, meaning the three-dimensional arrangement associated with a molecular structure. This matters because compounds with similar atom connectivity may still differ in spatial organization. Examining the represented arrangement helps chemists communicate and compare such structural distinctions during analysis and research.
Start by tracing the connected lines and locating every vertex and line end, then identify the explicitly written heteroatoms. Next, examine the overall carbon framework, attached functional groups, and any structural features relevant to stereochemistry. This sequence converts a compact drawing into information about connectivity, composition, and possible structural differences.
Chemists use this notation when they need to draw or interpret organic compounds efficiently without writing every attached hydrogen. Its compact format supports communication in research and education, especially when discussing larger carbon frameworks, functional groups, isomers, or reaction pathways. It reduces visual clutter while retaining the connectivity needed for structural analysis.
Comparing skeletal drawings makes structural changes easier to inspect, including alterations to the carbon framework, functional-group placement, or overall connectivity. Chemists can then relate those changes to expected differences in molecular properties and use the models to reason through reaction pathways. The drawings therefore serve as a bridge between structure, comparison, and chemical interpretation.