Engineering Design
Engineering Design - Related Videos
12:04
Mouse Genome Engineering Using Designer Nucleases
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Cited by 14 •
2014
Designer nucleases such as zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) can be used to modify the genome of mouse preimplantation embryos by triggering both the nonhomologous end joining (NHEJ) and homologous recombination (HR) pathways. These advances enable the rapid generation of mice with precise genetic modifications.
08:04
Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
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Cited by 24 •
2013
We designed a novel mechanical loading bioreactor that can apply uniaxial or biaxial mechanical strain to a cartilage biocomposite prior to transplantation into an articular cartilage defect.
11:16
Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis
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Cited by 15 •
2014
Neural-machine interfaces (NMI) have been developed to identify the user's locomotion mode. These NMIs are potentially useful for neural control of powered artificial legs, but have not been fully demonstrated. This paper presented (1) our designed engineering platform for easy implementation and development of neural control for powered lower limb prostheses and (2) an experimental setup and protocol in a laboratory environment to evaluate neurally-controlled artificial legs on patients with...
12:28
Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
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Cited by 2 •
2023
Three-dimensional cardiac tissues bioengineered using stem-cell-derived cardiomyocytes have emerged as promising models for studying healthy and diseased human myocardium in vitro while recapitulating key aspects of the native cardiac niche. This manuscript describes a protocol for fabricating and analyzing high-content engineered cardiac tissues generated from human induced pluripotent stem-cell-derived cardiomyocytes.
10:30
Design and Construction of Artificial Extracellular Matrix (aECM) Proteins from Escherichia coli for Skin Tissue Engineering
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Cited by 6 •
2015
Recombinant technologies have enabled material designers to create novel artificial proteins with customized functionalities for tissue engineering applications. For example, artificial extracellular matrix proteins can be designed to incorporate structural and biological domains derived from native ECMs. Here, we describe the construction and purification of aECM proteins containing elastin-like repeats.
FAQs
Engineers translate technical, economic, safety, and user requirements into specifications that can guide concept development and evaluation. These specifications make broad needs more concrete by establishing the conditions a proposed solution must satisfy. They also provide a basis for comparing alternatives and judging whether a product, structure, system, or technology addresses the original problem effectively.
Iteration allows engineers to identify weaknesses, test possible improvements, and refine a solution rather than relying on a single development attempt. Teams may move repeatedly among concept generation, modeling, prototyping, testing, and analysis. This cycle connects observed performance with revised decisions, helping the design better satisfy its technical requirements and broader project constraints.
Engineers compare alternatives against competing technical, economic, safety, and user requirements. Improving one characteristic can affect other aspects of performance or feasibility, so evaluation helps teams judge the overall balance among available concepts. Documenting these comparisons supports reasoned decisions and makes the selected approach understandable within the constraints of the project.
A typical workflow begins by defining a need, then translating requirements into specifications and generating possible concepts. Engineers evaluate those concepts, build models or prototypes, and apply testing and analysis to examine performance. Results from evaluation guide refinement, while documentation records the reasoning and comparisons that support progress toward a reliable solution.
Engineering design draws on scientific principles together with materials, manufacturing methods, computation, models, prototypes, testing, and analysis. Each resource contributes differently: scientific principles inform expected behavior, materials and manufacturing shape feasibility, computation supports development or evaluation, and physical or analytical checks reveal performance. Their combination helps teams connect proposed solutions with practical project requirements.
The process supports products, structures, systems, and technologies across engineering fields. Its value extends beyond creating an initial concept because testing, analysis, documentation, and evaluation help teams compare alternatives and refine performance. These activities support solutions intended to function reliably while addressing real-world needs and the technical, economic, safety, and user conditions established for the project.