Multimodal Particle Analysis

Multimodal particle analysis is an analytical approach that combines complementary measurements to characterize individual particles by properties such as size, shape, composition, and optical response. It integrates data from imaging, spectroscopy, light scattering, or other particle-measurement methods, allowing physical and chemical features to be evaluated together rather than in isolation. In environmental research, this approach helps distinguish and track aerosols, sediment particles, microplastics, and other particulate pollutants in complex samples. By linking particle characteristics with sources, transport, and environmental behavior, multimodal analysis supports more accurate monitoring, risk assessment, and evaluation of pollution-control strategies.

Multimodal Particle Analysis - Related Videos

Research

JoVE Journal - Environment
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Multimodal Analysis of Microplastics in Drinking Water using a Silicon Nanomembrane Analysis Pipeline

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2025

Here, we present a protocol showcasing an optically transparent and flat substrate for the streamlined capture and analysis of contaminating particles in drinking water. Presented here is the Silicon Nanomembrane Analysis Pipeline (SNAP): a flexible pipeline for the capture, quantification, and identification of particles in liquid media.

Research

JoVE Journal - Biology
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Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

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Cited by 9 •

2017

This manuscript uses the Fiji-based open-source software package VirusMapper to apply single-particle analysis to super-resolution microscopy images in order to generate precise models of nanoscale structure.

Research

JoVE Journal - Bioengineering

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

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2025

Utilizing a multimodal platform combining label-free optical imaging modalities, we have developed a protocol for visualizing and quantifying cellular dynamics and metabolism. Through imaging via multiphoton fluorescence, second harmonic generation, and stimulated Raman scattering microscopy, we can generate a holistic overview of the cellular and molecular environment.

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model

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Cited by 7 •

2018

Here, we present the usefulness of longitudinal in vivo imaging in the follow-up of morphological changes of laser-induced choroidal neovascularization in mice.

Research

JoVE Journal - Biochemistry
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High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE

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Cited by 218 •

2017

This paper presents a protocol for processing cryo-EM images using the software suite SPHIRE. The present protocol can be applied for nearly all single particle EM projects that target near-atomic resolution.

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