Local Extrema Analysis

Local extrema analysis is the study of where a function attains a relative maximum or minimum within a neighborhood, rather than across its entire domain. To locate and classify these points, examine the domain, identify critical numbers where the derivative is zero or undefined, and use a first-derivative sign chart or second-derivative test to determine whether the function changes from increasing to decreasing or vice versa. In mathematics, this analysis supports graphing, optimization, and interpretation of models by revealing nearby peaks and valleys, even when a global optimum does not exist. It also helps connect algebraic formulas with geometric behavior.

Local Extrema Analysis - Related Videos

Education

JoVE Core - Calculus

Absolute and Local Extreme Values

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2026

The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...

Research

JoVE Journal - Medicine

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

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2025

This protocol presents a step-by-step guide for performing minimally invasive isolated limb perfusion (MI-ILP), a treatment option for patients with locally advanced melanomas and sarcomas of the extremities.

Research

JoVE Journal - Biology
Free Sample

Heterokaryon Technique for Analysis of Cell Type-specific Localization

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Cited by 1 •

2011

A flexible and efficient method for the characterization of cell type-specific protein localization and nucleocytoplasmic shuttling is described. This heterokaryon approach uses fluorescently-labeled fusion proteins to image protein localizations after cell fusion. The protocol is amenable to steady-state localizations or more dynamic determinations based on live cell imaging.

Synthesis and Microdiffraction at Extreme Pressures and Temperatures

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Cited by 5 •

2013

The laser heated diamond anvil cell combined with synchrotron micro-diffraction techniques allows researchers to explore the nature and properties of new phases of matter at extreme pressure and temperature (PT) conditions. Heterogeneous samples can be characterized in situ under high pressure by 2D mapping and combined powder, single-crystal and multigrain diffraction approaches.

Single Molecule Analysis of Laser Localized Psoralen Adducts

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2017

Lasers are frequently used in studies of the cellular response to DNA damage. However, they generate lesions whose spacing, frequency, and collisions with replication forks are rarely characterized. Here, we describe an approach that enables the determination of these parameters with laser localized interstrand crosslinks.

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