Permanent Occlusion
Permanent Occlusion - Related Videos
08:22
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Cited by 14 •
2013
We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.
09:11
Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
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Cited by 15 •
2016
Here we present a protocol to produce permanent distal middle cerebral artery occlusion in elderly female rats with simultaneous occlusion of the carotid arteries to generate large cortical infarcts and sustained deficits. We show confirmation of the lesion size using structural MRI at 24 hr and 8 weeks after stroke.
08:14
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
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Cited by 103 •
2014
Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.
09:59
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Cited by 17 •
2017
A protocol for stroke onset time estimation in a rat model of stroke exploiting quantitative magnetic resonance imaging (qMRI) parameters is described. The procedure exploits diffusion MRI for delineation of the acute stroke lesion and quantitative T1 and T2 (qT1 and qT2) relaxation times for timing of stroke.
06:28
Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model
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Cited by 194 •
2011
Filamentous occlusion of the Middle cerebral artery is a common model for studying ischemic stroke in mice.
FAQs
Changes in permanent occlusion reflect coordination between tooth eruption and jaw growth, not eruption alone. As primary teeth are replaced, permanent teeth establish contacts within the arches while the jaws continue developing. The resulting intercuspation, meaning the way opposing tooth cusps fit together, can therefore change as skeletal growth and tooth positioning alter the closing and chewing relationship.
Tooth contacts and intercuspation help determine how chewing forces are distributed across the dentition. When opposing surfaces meet in a stable pattern, forces can be shared through the teeth and their supporting periodontal tissues. Jaw movement and neuromuscular control then coordinate opening, closing, and chewing, linking the contact pattern to both function and bite stability.
They influence how teeth tolerate and respond to functional loading. Periodontal support provides the tissue foundation around the teeth, while neuromuscular control regulates jaw motion and muscle coordination. Considering both prevents assessment from focusing only on tooth position and helps explain why similar contact patterns may have different functional consequences.
Clinicians assess how the upper and lower teeth contact when the jaws close and move during chewing. They consider intercuspation, alignment within the arches, bite stability, jaw growth, periodontal support, and neuromuscular control. This assessment can identify malocclusion and clarifies how forces may be distributed during function, rather than recording tooth position in isolation.
Findings provide functional information for orthodontic, restorative, and prosthodontic care. They can help clinicians identify malocclusion, assess whether the bite is stable, and account for tooth contacts and force distribution when planning treatment. This makes the evaluation relevant not only to alignment, but also to preserving or restoring coordinated jaw function.
It can help connect dental relationships with efficient mastication, tooth wear, and the consequences of altered alignment. Because chewing depends on coordinated contacts, jaw movement, periodontal support, and neuromuscular control, a changed bite may have functional significance beyond appearance. Assessment therefore supports interpretation of how alignment relates to oral performance and bite stability.